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Development of the CRISPR nuclease Cas9 for high precision mammalian genome engineering
Recent advances in genome engineering technologies based on the CRISPR-associated RNA-guided endonuclease Cas9 are enabling the systematic interrogation of genome function. Analogous to the search function in modern word ...
CRISPR-Cas: Development and applications for mammalian genome editing
The ability to introduce targeted modifications into genomes and engineer model organisms holds enormous promise for biomedical and technological applications, and has driven the development of tools such as zinc finger ...
Genome Engineering Technology and Its Application in Mammalian Cells
The advancement of high-throughput, large-scale biochemical, biophysical, and genetic technologies has enabled the generation of massive amounts of biological data and allowed us to synthesize various types of biomaterial ...