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Chemical Probes and the Exploration of Bromodomains in Cancer Biology
(2014-06-06)
The post-translational modification of histones and their interaction with transcription factors is essential to gene regulation. Furthermore, these targets would greatly benefit from probe molecules to fully elucidate ...
Mechanism of endoplasmic reticulum membrane fusion mediated by the Atlastin GTPase
(2014-10-21)
How organelles acquire their unique shapes is a fundamental question of cell biology. The peripheral endoplasmic reticulum (ER) consists of a vast network of membrane sheets and tubules, the formation of which requires ...
Development of Methods for Protein Delivery and the Directed Evolution of Recombinases
(2014-10-22)
As a class, protein-based therapeutics offer tremendous advantages over traditional small molecule drugs. Due to their sizes and folding energies, proteins are ideal for catalyzing chemical reactions, and can bind tightly ...