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Memory in a phenotypic switch and noise in gene networks
(2014-02-25)
Many cell types stochastically switch phenotypes under some conditions, so that genetically identical sister cells may behave quite differently in a common environment. This non-genetic variability likely arises from noise ...
Fluctuation Timescales in Bacterial Gene Expression
(2014-02-25)
The stochastic nature of intracellular chemistry guarantees that even genetically identical cells sharing an environment will differ in composition. The question of whether this chemical diversity translates into significant ...
Structural insights into the assembly and dynamics of the ATP-dependent chromatin-remodeling complex SWR1
(2014-06-06)
The ATP-dependent chromatin remodeling complex SWR1 exchanges a variant histone H2A.Z-H2B dimer for a canonical H2A-H2B dimer at nucleosomes flanking histone-depleted regions, such as promoters. This localization of H2A.Z ...