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Characterization of the Antibacterial Activity of the Type VI Secretion System
(2014-02-25)
This dissertation summarizes advances made toward understanding of the composition, structure, mechanism, and regulation of the bacterial type VI secretion system (T6SS). The T6SS is a widely conserved bacterial nanomachine ...
Genome Engineering Technology and Its Application in Mammalian Cells
(2014-06-06)
The advancement of high-throughput, large-scale biochemical, biophysical, and genetic technologies has enabled the generation of massive amounts of biological data and allowed us to synthesize various types of biomaterial ...
Optical control of mammalian endogenous transcription and epigenetic states
(2014-06-06)
The dynamic nature of gene expression enables cellular programming, homeostasis and environmental adaptation in living systems. Dissection of causal gene functions in cellular and organismal processes therefore necessitates ...
Investigating Synthetic Lethal Interactions with the Wall Teichoic Acid Pathway of Staphylococcus aureus
(2014-06-06)
The peptidoglycan of many Gram-positive bacteria is densely functionalized with anionic glycopolymers called wall teichoic acids (WTAs). Recent studies have shown that these polymers play crucial roles in cell shape ...
Dietary Restriction-Induced Longevity in Caenorhabditis elegans: Mediated by Stress Defense, NAD\(^+\)-Dependent Mechanisms and a Respiratory Shift
(2014-06-06)
Dietary restriction (DR), or the reduction of food consumption without malnutrition, is the most conserved method of preventing or reversing age associated diseases. It is also the most conserved method of increasing ...
Exploring the role of microRNAs in airway smooth muscle biology and asthma therapy
(2014-06-06)
The pathophysiology of asthma is characterized by airway inflammation, remodeling and hyper-responsiveness. Phenotypic changes in airway smooth muscle cells (ASM) play a pivotal role in the pathogenesis of asthma. ASM cells ...