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Genetic Basis of Natural Variation in Cellular Decision Making in Wild Yeasts
(2018-05-15)
In nature, microbes often need to decide which of many potential nutrients to consume. This decision-making process is complex, involving both intracellular constraints and the organism’s perception of the environment. ...
Intergenerational Transmission of Non-Germline RNAs in Caenorhabditis Elegans
(2018-05-13)
In the model organism Caenorhabditis elegans, double-stranded RNA (dsRNA) capable of silencing genes can be introduced anywhere in the animal and will subsequently travel throughout the body and enter most cells, including ...
α-Synuclein Induces Mitochondrial Dysfunction Through Spectrin and the Actin Cytoskeleton
(2018-09-16)
Abnormal accumulation of the cytoplasmic protein α-synuclein in vulnerable neurons and glial is a pathological hallmark of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, collectively termed ...
Temporal Regulation of Chromatin Organization During C. Elegans Embryogenesis
(2018-05-01)
In all eukaryotic cells, the genetic material is organized into a complex structure composed of DNA and protein: chromatin. Organization of chromatin structure in the nucleus influences all functions of the genome including ...