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On Clocks and Tuners: Cyanobacterial Strategies to Thrive in a Dynamic Environment
(2018-01-05)
The cycle of day and night is among the most recurrent and predictable environmental changes. In order to thrive, organisms across all domains of life evolved regulatory strategies to respond to diurnal fluctuations in ...
Integrating Regulatory Information in Eukaryotic Transcription
(2018-08-17)
Transcriptional regulation is a key determinant of cell differentiation during development. Changes in where and when a gene is expressed can lead to phenotypic variation among individuals, and ultimately to phenotypic ...
Genetic Basis of Natural Variation in Cellular Decision Making in Wild Yeasts
(2018-05-15)
In nature, microbes often need to decide which of many potential nutrients to consume. This decision-making process is complex, involving both intracellular constraints and the organism’s perception of the environment. ...
Intergenerational Transmission of Non-Germline RNAs in Caenorhabditis Elegans
(2018-05-13)
In the model organism Caenorhabditis elegans, double-stranded RNA (dsRNA) capable of silencing genes can be introduced anywhere in the animal and will subsequently travel throughout the body and enter most cells, including ...
Msp1 Protects Organelles Through Quality Control of Excess Membrane Proteins
(2018-01-16)
Quality control (QC) of membrane proteins is a critical but ill-understood process where undesirable proteins are sequestered or eliminated to protect cellular homeostasis. A recently described membrane protein QC pathway ...
Mesendoderm Patterning by Vg1/Nodal Heterodimers
(2018-05-14)
One of the key processes during development is the induction of the mesoderm and endoderm (mesendoderm), which generates the precursors of the heart, liver, gut, pancreas, kidney and other internal organs. Nodal, a member ...
Engineering High-Precision CRISPR-Cas9 Nuclease and Base Editor Technologies
(2018-05-16)
The human genome, comprising approximately three billion nucleotides separated across 23 chromosomes, contains a vast amount of sequence space encoding instructions for the production of RNA and protein molecules that make ...
Temporal Regulation of Chromatin Organization During C. Elegans Embryogenesis
(2018-05-01)
In all eukaryotic cells, the genetic material is organized into a complex structure composed of DNA and protein: chromatin. Organization of chromatin structure in the nucleus influences all functions of the genome including ...
Translational control through differential ribosome pausing during amino acid limitation in mammalian cells
(2018-01-17)
Limitation for amino acids is thought to regulate translation in mammalian cells primarily by signaling through the kinases mTORC1 and GCN2. We find that limitation for the amino acid arginine causes a selective loss of ...
Optimizing Nanodiscs for Membrane Proteins and Mapping a Translation Initiation Complex
(2018-09-26)
Nanodiscs have been an excellent tool for encouraging biochemists and structural biologists to study membrane proteins. They are composed of a discoidal lipid bilayer and two copies of a membrane scaffold protein (MSP). ...