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The Design and Characterization of Bifunctional Degraders of TRIM24, a Novel Transcriptional Dependency in Hematologic Malignancies
Transcriptional control is critical to the proper functioning of cells, their growth, differentiation, and survival. Because genomic and epigenomic alterations can deregulate transcription and promote an oncogenic state, ...
Elucidating the Functions of CDK8 and CDK19 in Acute Myeloid Leukemia
Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...
Optimizing Nanodiscs for Membrane Proteins and Mapping a Translation Initiation Complex
Nanodiscs have been an excellent tool for encouraging biochemists and structural biologists to study membrane proteins. They are composed of a discoidal lipid bilayer and two copies of a membrane scaffold protein (MSP). ...
Functional analysis of multiple activities associated with the herpes simplex virus-1 DNA polymerase
Of the DNA replication proteins required for herpes simplex virus-1 (HSV-1) viral replication, the catalytic subunit of the DNA polymerase (Pol) has been the most extensively studied, both as a model for Family B polymerases ...