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Discovery and Characterization of the Cylindrocyclophane Biosynthetic Pathway
(2016-05-17)
Nature constructs structurally diverse, bioactive molecules using enzymes. Many enzymes catalyze synthetically challenging reactions under mild, physiological conditions. Consequently, they have long been a source of ...
Understanding and Preventing Disease-Associated Anaerobic Choline Metabolism by the Human Gut Microbiota
(2016-05-17)
The consortium of microorganisms inhabiting the human gastrointestinal tract, our gut microbiota, has an extensive set of metabolic capabilities that directly influence human health. Over the past decade, DNA sequencing ...
Chemical Neurobiology of the Histone Lysine Demethylase KDM1A
(2016-05-18)
Epigenetic mechanisms regulate gene expression and mediate interactions between genetic factors and environmental exposures. The enzymes responsible for epigenetic regulation may thus be important therapeutic targets for ...
Towards Self-Replicating Informational Polymers
(2016-05-16)
The capability to transmit information from generation to generation is an essential feature of life. In all terrestrial life, DNA and RNA contain information in the form of a sequence of monomers and are copied in every ...
Investigations of the Biosynthesis and Structure of Colibactin, a Cytotoxin Made by Human-Associated Escherichia Coli
(2016-01-13)
Humans exist in symbiosis with trillions of bacteria that are collectively referred to as the human microbiota. While commensal microbes are essential for health, some resident microbes can promote disease. Certain strains ...
Discovery and Characterization of Novel smORF-Encoded Polypeptides (SEPs)
(2016-01-04)
Peptides and small proteins have essential physiological roles including metabolism (insulin), sleep (orexin), and stress (corticotropin-releasing hormone). Recent exploration of the human genome and proteome has revealed ...
An antibiotic binds to the ATPase that powers lipopolysaccharide transport
(2016-07-05)
The spread of antibiotic resistance has created an urgent need for new antibiotics. The situation is particularly serious for Gram-negative bacteria because they possess an outer membrane (OM) that prevents many antibiotics ...
Identifying targets for potentiators in S. aureus using chemical genetic approaches
(2016-09-29)
Staphylococcus aureus is a highly feared Gram-positive pathogen. The rise in antibiotic resistance has made S. aureus infections intractable. To find new ways to treat S. aureus infections, it is important to understand ...
Cell-Based Discovery Methods Furnish New Compounds Effective Against Gram-Negative Bacteria
(2016-07-20)
Bacterial resistance to antibiotics inevitably results from their clinical use, and we have to continuously develop new antibiotics to stay ahead in this biological arms race. It is particularly important and challenging ...
Peptide-Assisted Nonenzymatic RNA Replication in Coacervate Droplets
(2016-09-14)
Life on earth may have first appeared in the form of a protocell capable of metabolism and containing a self-replicating informational polymer. This polymer was likely to have been RNA due to its ability to serve both as ...