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Elucidating the Functions of CDK8 and CDK19 in Acute Myeloid Leukemia
(2018-04-19)
Transcriptional dysregulation is an important cause of acute myeloid leukemia (AML). The majority of mutations in AML reside in genes that encode transcriptional regulators including transcription factors, chromatin ...
Nonhydrolyzable Ribonucleotide Phosphoroimidazolide Analogues for Mechanistic Studies of Nonenzymatic RNA Replication
(2018-04-17)
Efficient and faithful replication of genomic information is perhaps one of the most important hallmarks of cellular life. At some early point, such processes must have occurred in the absence of elaborate nucleic acid or ...