Cleft lip and/or palates (CL/P) are common congenital malformations, and mutations in the transcription factor IRF6 are the most significant genetic contributors to cleft pathogenesis. IRF6 is a master regulator of epithelial ...

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively reversed to unmodified cytosine through ten-eleven translocation (TET) dioxygenase-mediated oxidation of 5mC to 5-hydroxymethylcytosine ...

Pseudomonas aeruginosa is a Gram-negative opportunistic human pathogen found ubiquitously in both natural and manmade environments. Central to its ability to grow in different environments is the organism’s coordinated ...

Transcriptional control is critical to the proper functioning of cells, their growth, differentiation, and survival. Because genomic and epigenomic alterations can deregulate transcription and promote an oncogenic state, ...

Biological systems self-organize into complex well-ordered structures and can evolve new patterns when perturbed. To identify principles underlying self-organization, I turned to the model organism C. elegans for its ...

Organisms evolve to thrive in new environments. In spite of the role metabolism plays in adaptation, the genetic basis for metabolic variation remains poorly understood. Here we use independently derived populations of ...

The emergence of single-cell technologies has highlighted the potential to discover novel cellular subpopulations and states within heterogeneous populations. Such technologies are achieving increasingly higher-throughput, ...

Embryos pattern themselves with remarkable consistency and readily adjust their patterning programs to drastic changes in embryo size. This robustness of pattern formation, termed scale invariance, requires cells to determine ...

The ability to manipulate the genome has been a longstanding goal since the discovery of the central dogma of molecular biology. Such a technology would not only allow us to correct deleterious mutations for human therapeutics ...

Breast cancer is predicted to be the most frequent newly diagnosed cancer and second leading cause of cancer-associated death among women in the United States in 2018. Intratumoral heterogeneity plays an important role in ...