Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three genes, PIP4K2A, PIP4K2B and PIP4K2C that encode the enzymes ...

The NF1 tumor suppressor is lost or mutated in a variety of sporadic cancers, as well as in the hereditary cancer predisposition syndrome neurofibromatosis type 1 (NF1). NF1 patients have an 8–13% risk of developing a ...

The epigenetic regulation of gene transcription underlies the diversity between species and within organisms. Novel implementation of existing methods and the development of original technologies continue to contribute ...

Since their divergence from a common ancestor some 200 million years ago, mammals have undergone significant diversification in physiology, morphology, habitat, size, and longevity. The maximum lifespan of mammalian species ...

The establishment of proper proportions during development is essential for the final form and function of an organism. While much is known concerning the regulation of proliferation and differentiation, how the relative ...

The ability to manipulate the genome has been a longstanding goal since the discovery of the central dogma of molecular biology. Such a technology would not only allow us to correct deleterious mutations for human therapeutics ...

Breast cancer is predicted to be the most frequent newly diagnosed cancer and second leading cause of cancer-associated death among women in the United States in 2018. Intratumoral heterogeneity plays an important role in ...