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Molecular Determinants and Transcriptional Regulators in Triple Negative Breast Cancer
(2015-08-07)
Breast cancer is a highly heterogeneous disease with differences in histopathological and biological characteristics, variable prognoses, and response to therapy. Clinically, breast
tumors are classified based on the ...
In Vivo and in Vitro Characterization of the Tumor Suppressive Function of INPP4B
(2015-05-16)
The phosphatases PTEN and INPP4B are frequently deregulated in human cancer and have been proposed to act as tumor suppressor genes by coordinately antagonizing PI3K/AKT signaling. While the function of PTEN has been ...
The Metabolic Role of the Hippo Pathway in Liver Development and Cancer
(2015-05-12)
Hepatocellular carcinoma (HCC) is a global health problem with poor prognosis and limited therapeutic options. While the clinical risk factors for HCC are well described, the precise molecular and metabolic mechanisms ...
Interrogation of the RP-MDM2-P53 Axis in Human Ribosomopathies
(2015-05-15)
Ribosomopathies such as Diamond-Blackfan anemia (DBA) and 5q- syndrome are human diseases characterized by heterozygous loss or mutation of ribosome-associated genes. Hallmarks of these diseases include a macrocytic anemia ...
Developments in Human Pluripotent Stem Cell Genome Engineering and in Situ Sequencing Technologies
(2015-05-19)
Technology is a key driving force in the advancement of scientific discoveries. While DNA sequencing uncovered the blueprint of life encoded in the human genome, functional roles of sequence variants remain largely unknown. ...