Search
Now showing items 1-5 of 5
Isogenic Human Pluripotent Stem Cell Models of Cardiovascular Disease-Associated Genetic Variation
(2016-03-30)
A complex interplay of genetic and environmental factors underlies the development of common human diseases such as cardiovascular disease. Despite widespread use of existing medications, coronary heart disease (CHD), ...
Organization of Postsynaptic Assembly by Filamin at the Drosophila Neuromuscular Junction
(2016-05-16)
Proper postsynaptic assembly is a fundamental requirement for circuit function, yet our understanding of its molecular mechanism is incomplete. The Drosophila neuromuscular junction is a powerful system for genetically ...
Homology and Heterology Effects in Drosophila: Cohesin and Condensin as Chromosome Choreographers
(2016-05-02)
The organization of interphase nuclei has numerous consequences for gene expression and genome stability in eukaryotes. Here, we present studies of chromosome organization in Drosophila melanogaster over the course of the ...
Estrogen Signaling in Breast Tumorigenesis
(2016-09-09)
The estrogen receptor (ER) is expressed in approximately 70% of sporadic breast cancers and is believed to activate genes driving tumorigenesis and initial cell proliferation. Therapeutic targeting of the ER signaling ...
A genetic dissection of the interactions between the CbtA toxin of Escherichia coli and the bacterial cytoskeleton
(2016-09-15)
Prokaryotic chromosomal toxin-antitoxin (TA) systems, consisting of a stable toxin and a labile, cotranscribed antitoxin, have been shown to target a number of essential processes in bacteria. The Escherichia coli genome ...