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Towards Sense Codon Reassignment in Escherichia Coli
(2015-10-23)
Expansion of the genetic code through engineering of the translation machinery has vastly increased the chemical repertoire of the proteome. Incorporation of non-canonical amino acids (ncAAs) entails use of engineered ...
The Design and Characterization of Bifunctional Degraders of TRIM24, a Novel Transcriptional Dependency in Hematologic Malignancies
(2018-04-24)
Transcriptional control is critical to the proper functioning of cells, their growth, differentiation, and survival. Because genomic and epigenomic alterations can deregulate transcription and promote an oncogenic state, ...