Pathobiology of Experimental Acute Pancreatitis

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Pathobiology of Experimental Acute Pancreatitis

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Title: Pathobiology of Experimental Acute Pancreatitis
Author: Steer, Michael Lewis
Citation: Steer, M. L. 1992. Pathobiology of experimental acute pancreatitis. The Yale Journal of Biology and Medicine 65(5): 421-440.
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Abstract: Pancreatic duct obstruction, even in the absence of biliary obstruction and/or bile reflux into the pancreatic duct, can trigger acute hemorrhagic necrotizing pancreatitis. The earliest changes are seen within acinar cells. Early derangements in acinar cell biology include inhibition of digestive enzyme secretion and the co-localization of lysosomal hydrolases with digestive enzyme zymogens. Under appropriate conditions, this co-localization could lead to digestive enzyme activation within acinar cells.
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