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dc.contributor.authorKeinan, Alon
dc.contributor.authorReich, David Emil
dc.date.accessioned2011-07-01T14:00:54Z
dc.date.issued2010
dc.identifier.citationKeinan, Alon, and David Reich. 2010. Human population differentiation is strongly correlated with local recombination rate. PLoS Genetics 6(3): e1000886.en_US
dc.identifier.issn1553-7390en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:4931150
dc.description.abstractAllele frequency differences across populations can provide valuable information both for studying population structure and for identifying loci that have been targets of natural selection. Here, we examine the relationship between recombination rate and population differentiation in humans by analyzing two uniformly-ascertained, whole-genome data sets. We find that population differentiation as assessed by inter-continental \(F_{ST}\) shows negative correlation with recombination rate, with \(F_{ST}\) reduced by 10% in the tenth of the genome with the highest recombination rate compared with the tenth of the genome with the lowest recombination rate \((P\ll10^{-12})\). This pattern cannot be explained by the mutagenic properties of recombination and instead must reflect the impact of selection in the last 100,000 years since human continental populations split. The correlation between recombination rate and \(F_{ST}\) has a qualitatively different relationship for \(F_{ST}\) between African and non-African populations and for \(F_{ST}\) between European and East Asian populations, suggesting varying levels or types of selection in different epochs of human history.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pgen.1000886en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845648/pdf/en_US
dash.licenseLAA
dc.subjectcomputational biologyen_US
dc.subjectpopulation geneticsen_US
dc.subjectevolutionary biologyen_US
dc.subjecthuman evolutionen_US
dc.subjectgenetics and genomicsen_US
dc.titleHuman Population Differentiation is Strongly Correlated With Local Recombination Rateen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Geneticsen_US
dash.depositing.authorReich, David Emil
dc.date.available2011-07-01T14:00:54Z
dash.affiliation.otherHMS^Geneticsen_US
dc.identifier.doi10.1371/journal.pgen.1000886*
dash.contributor.affiliatedReich, David


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