Effect of Vitamin K Supplementation on Insulin Resistance in Older Men and Women

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Effect of Vitamin K Supplementation on Insulin Resistance in Older Men and Women

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Title: Effect of Vitamin K Supplementation on Insulin Resistance in Older Men and Women
Author: Yoshida, Makiko; Jacques, Paul F.; Saltzman, Edward; Gundberg, Caren; Dawson-Hughes, Bess; Dallal, Gerard; Booth, Sarah L.; Meigs, James Benjamin; Shea, M. Kyla

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Citation: Yoshida, Makiko, Paul F. Jacques, James B. Meigs, Edward Saltzman, M. Kyla Shea, Caren Gundberg, Bess Dawson-Hughes, Gerard Dallal, and Sarah L. Booth. 2008. Effect of vitamin K supplementation on insulin resistance in older men and women. Diabetes Care 31(11): 2092-2096.
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Abstract: Objective: Vitamin K has a potentially beneficial role in insulin resistance, but evidence is limited in humans. We tested the hypothesis that vitamin K supplementation for 36 months will improve insulin resistance in older men and women. Research Design and Methods: This was an ancillary study of a 36-month, randomized, double-blind, controlled trial designed to assess the impact of supplementation with 500 μg/day phylloquinone on bone loss. Study participants were older nondiabetic men and women (n = 355; aged 60–80 years; 60% women). The primary outcome of this study was insulin resistance as measured by homeostasis model assessment (HOMA-IR) at 36 months. Fasting plasma insulin and glucose were examined as the secondary outcomes. Results: The effect of 36-month vitamin K supplementation on HOMA-IR differed by sex (sex × treatment interaction P = 0.02). HOMA-IR was statistically significantly lower at the 36-month visit among men in the supplement group versus the men in the control group (P = 0.01) after adjustment for baseline HOMA-IR, BMI, and body weight change. There were no statistically significant differences in outcome measures between intervention groups in women. Conclusions: Vitamin K supplementation for 36 months at doses attainable in the diet may reduce progression of insulin resistance in older men.
Published Version: doi:10.2337/dc08-1204
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571052/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5024677
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