Genomic Screening in Family-Based Association Testing
View/ Open
Author
Murphy, Amy
McQueen, Matthew B
Kraft, Peter
Van Steen, Kristel
Published Version
https://doi.org/10.1186/1471-2156-6-S1-S115Metadata
Show full item recordCitation
Murphy, Amy, Matthew B. McQueen, Jessica Su, Peter Kraft, Ross Lazarus, Nan M. Laird, Christoph Lange, and Kristel Van Steen. 2005. Genomic screening in family-based association testing. BMC Genetics 6(Suppl 1):S115.Abstract
Due to the recent gains in the availability of single-nucleotide polymorphism data, genome-wide association testing has become feasible. It is hoped that this additional data may confirm the presence of disease susceptibility loci, and identify new genetic determinants of disease. However, the problem of multiple comparisons threatens to diminish any potential gains from this newly available data. To circumvent the multiple comparisons issue, we utilize a recently developed screening technique using family-based association testing. This screening methodology allows for the identification of the most promising single-nucleotide polymorphisms for testing without biasing the nominal significance level of our test statistic. We compare the results of our screening technique across univariate and multivariate family-based association tests. From our analyses, we observe that the screening technique, applied to different settings, is fairly consistent in identifying optimal markers for testing. One of the identified markers, TSC0047225, was significantly associated with both the ttth1 (p = 0.004) and ttth1-ttth4 (p = 0.004) phenotype(s). We find that both univariate- and multivariate-based screening techniques are powerful tools for detecting an association.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866823/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:5025436
Collections
- HMS Scholarly Articles [17917]
- SPH Scholarly Articles [6362]
Contact administrator regarding this item (to report mistakes or request changes)