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dc.contributor.authorCantonwine, David
dc.contributor.authorHu, Howard
dc.contributor.authorTéllez-Rojo, Martha Maria
dc.contributor.authorSánchez, Brisa N
dc.contributor.authorLamadrid-Figueroa, Héctor
dc.contributor.authorMercado-García, Adriana
dc.contributor.authorHernández-Avila, Mauricio
dc.contributor.authorEttinger, Adrienne S
dc.contributor.authorWright, Robert O.
dc.date.accessioned2011-09-13T03:34:35Z
dc.date.issued2010
dc.identifier.citationCantonwine, David, Howard Hu, Martha Maria Téllez-Rojo, Brisa N Sánchez, Héctor Lamadrid-Figueroa, Adrienne S Ettinger, Adriana Mercado-Garcí­a, Mauricio Hernández-Avila, and Robert O Wright. 2010. HFE gene variants modify the association between maternal lead burden and infant birthweight: a prospective birth cohort study in Mexico City, Mexico. Environmental Health 9: 43.en_US
dc.identifier.issn1476-069Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5129840
dc.description.abstractBackground: Neonatal growth is a complex process involving genetic and environmental factors. Polymorphisms in the hemochromatosis (HFE) iron regulatory genes have been shown to modify transport and toxicity of lead which is known to affect birth weight. Methods: We investigated the role of HFE C282Y, HFE H63 D, and transferrin (TF) P570 S gene variants in modifying the association of lead and infant birthweight in a cohort of Mexican mother-infant pairs. Subjects were initially recruited between 1994-1995 from three maternity hospitals in Mexico City and 411 infants/565 mothers had archived blood available for genotyping. Multiple linear regression models, stratified by either maternal/infant HFE or TF genotype and then combined with interaction terms, were constructed examining the association of lead and birthweight after controlling for covariates. Results: 3.1%, 16.8% and 17.5% of infants (N = 390) and 1.9%, 14.5% and 18.9% of mothers (N = 533) carried the HFE C282Y, HFE H63D, and TF P570 S variants, respectively. The presence of infant HFE H63 D variants predicted 110.3 g (95% CI -216.1, -4.6) decreases in birthweight while maternal HFE H63 D variants predicted reductions of 52.0 g (95% CI -147.3 to 43.2). Interaction models suggest that both maternal and infant HFE H63 D genotype may modify tibia lead's effect on infant birthweight in opposing ways. In our interaction models, maternal HFE H63 D variant carriers had a negative association between tibia lead and birthweight. Conclusions: These results suggest that the HFE H63 D genotype modifies lead's effects on infant birthweight in a complex fashion that may reflect maternal-fetal interactions with respect to the metabolism and transport of metals.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/1476-069X-9-43en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916893/pdf/en_US
dash.licenseLAA
dc.titleHFE Gene Variants Modify the Association between Maternal Lead Burden and Infant Birthweight: A Prospective Birth Cohort Study in Mexico City, Mexicoen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Healthen_US
dash.depositing.authorEttinger, Adrienne S
dc.date.available2011-09-13T03:34:35Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dc.identifier.doi10.1186/1476-069X-9-43*
dash.authorsorderedfalse
dash.contributor.affiliatedEttinger, Adrienne
dash.contributor.affiliatedWright, Robert


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