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dc.contributor.authorLeung, Yuet-Kin
dc.contributor.authorLam, Hung-Ming
dc.contributor.authorSong, Dan
dc.contributor.authorLevin, Linda
dc.contributor.authorHo, Shuk-Mei
dc.contributor.authorWu, Shulin
dc.contributor.authorCheng, Liang
dc.contributor.authorWu, Chin-Lee
dc.date.accessioned2011-09-24T21:09:14Z
dc.date.issued2010
dc.identifier.citationLeung, Yuet-Kin, Hung-Ming Lam, Shulin Wu, Dan Song, Linda Levin, Liang Cheng, Chin-Lee Wu, and Shuk-Mei Ho. 2010. Estrogen receptor β2 and β5 are associated with poor prognosis in prostate cancer, and promote cancer cell migration and invasion. Endocrine-Related Cancer 17(3): 675-689.en_US
dc.identifier.issn1351-0088en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5141357
dc.description.abstractEstrogens play a pivotal role in the development and progression of prostate cancer (PCa). Their actions are mediated by estrogen receptors (ERs), particularly ERβ in the prostate epithelium. With the discovery of ERβ isoforms, data from previous studies that focused principally on the wild-type ERβ (ERβ1) may not be adequate in explaining the still controversial role of ERβ(s) in prostate carcinogenesis. In this study, using newly generated isoform-specific antibodies, immunohistochemistry (IHC) was performed on a tumor microarray comprised of 144 specimens. IHC results were correlated with pathological and clinical follow-up data to delineate the distinct roles of ERβ1, ERβ2, and ERβ5 in PCa. ERβ2 was commonly found in the cytoplasm and was the most abundant isoform followed by ERβ1 localized predominantly in the nucleus, and ERβ5 was primarily located in the cytoplasm. Logistic regression analyses demonstrated that nuclear ERβ2 (nERβ2) is an independent prognostic marker for prostate specific antigen (PSA) failure and postoperative metastasis (POM). In a Kaplan–Meier analysis, the combined expression of both nERβ2 and cytoplasmic ERβ5 identified a group of patients with the shortest POM-free survival. Cox proportional hazard models revealed that nERβ2 predicted shorter time to POM. In concordance with IHC data, stable, ectopic expression of ERβ2 or ERβ5 enhanced PCa cell invasiveness but only PCa cells expressing ERβ5 exhibited augmented cell migration. This is the first study to uncover a metastasis-promoting role of ERβ2 and ERβ5 in PCa, and show that the two isoforms, singularly and conjointly, have prognostic values for PCa progression. These findings may aid future clinical management of PCa.en_US
dc.language.isoen_USen_US
dc.publisherSociety for Endocrinologyen_US
dc.relation.isversionofdoi://10.1677/ERC-09-0294en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891483/pdf/en_US
dash.licenseLAA
dc.titleEstrogen Receptor β2 and β5 are Associated with Poor Prognosis in Prostate Cancer, and Promote Cancer Cell Migration and Invasionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEndocrine-Related Canceren_US
dash.depositing.authorWu, Shulin
dc.date.available2011-09-24T21:09:14Z
dash.affiliation.otherHMS^Pathologyen_US
dash.affiliation.otherHMS^Pathologyen_US
dc.identifier.doi10.1677/ERC-09-0294*
dash.authorsorderedfalse
dash.contributor.affiliatedWu, Chin-Lee
dash.contributor.affiliatedWu, Shulin


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