The Prolyl Isomerase Pin1 in Breast Development and Cancer

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The Prolyl Isomerase Pin1 in Breast Development and Cancer

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Title: The Prolyl Isomerase Pin1 in Breast Development and Cancer
Author: Ryo, Akihide; Liou, Yih-Cherng; Wulf, Gerburg Maria; Lu, Kun Ping

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Citation: Wulf, Gerburg, Akihide Ryo, Yih-Cherng Liou, and Kun Ping Lu. 2003. The prolyl isomerase Pin1 in breast development and cancer. Breast Cancer Research 5(2): 76-82.
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Abstract: The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is overexpressed in human breast cancer. Its overexpression can lead to upregulation of cyclin D1 and transformation of breast epithelial cells in collaboration with the oncogenic pathways. In contrast, inhibition of Pin1 can suppress the transformation of breast epithelial cells. In addition, Pin1 knockout in mice prevents massive proliferation of breast epithelial cells during pregnancy. Pin1 plays a pivotal role in breast development and may be a promising new anticancer target.
Published Version: http://www.biomedcentral.com/content/pdf/bcr572.pdf
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154150/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5332801
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