Assisted Assembly: How to Improve a De Novo Genome Assembly By Using Related Species
Jaffe, David B
MetadataShow full item record
CitationGnerre, Sante, Eric S Lander, Kerstin Lindblad-Toh, and David B Jaffe. 2009. Assisted assembly: how to improve a de novo genome assembly by using related species. Genome Biology 10(8): R88.
AbstractWe describe a new assembly algorithm, where a genome assembly with low sequence coverage, either throughout the genome or locally, due to cloning bias, is considerably improved through an assisting process via a related genome. We show that the information provided by aligning the whole-genome shotgun reads of the target against a reference genome can be used to substantially improve the quality of the resulting assembly.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5334258
- HMS Scholarly Articles