Show simple item record

dc.contributor.authorNolting, Jens
dc.contributor.authorReuter, Sabine
dc.contributor.authorStuelten, Christina
dc.contributor.authorLi, Peng
dc.contributor.authorSucov, Henry
dc.contributor.authorKim, Byung-Gyu
dc.contributor.authorLetterio, John J.
dc.contributor.authorKretschmer, Karsten
dc.contributor.authorDaniel, Carolin
dc.contributor.authorKim, Hye-Jung
dc.contributor.authorvon Boehmer, Harald
dc.date.accessioned2011-11-01T15:10:18Z
dc.date.issued2009
dc.identifier.citationNolting, Jens, Carolin Daniel, Sabine Reuter, Christina Stuelten, Peng Li, Henry Sucov, Byung-Gyu Kim, et al. 2009. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. The Journal of Experimental Medicine 206(10): 2131-2139.en_US
dc.identifier.issn0022-1007en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5336035
dc.description.abstractIt has been reported that retinoic acid (RA) enhances regulatory T (T reg) cell conversion by inhibiting the secretion of cytokines that interfere with conversion. This report shows that these conclusions provide a partial explanation at best. First, RA not only interfered with cytokine secretion but also with the ability of these cytokines to inhibit T reg cell conversion of naive T cells. Furthermore, RA enhanced conversion even in the absence of inhibitory cytokines. The latter effect depended on the RA receptor α (RARα) but did not require Smad3, despite the fact that RA enhanced Smad3 expression. The RARα1 isoform was not essential for RA-dependent enhancement of transforming growth factor β–driven conversion, suggesting that conversion can also be mediated by RARα2. Interleukin (IL)-6 strongly reduced RARα expression levels such that a deficiency of the predominant RARα1 isoform leaves too little RARα2 for RA to inhibit the generation of Th17 cells in the presence of IL-6.en_US
dc.language.isoen_USen_US
dc.publisherThe Rockefeller University Pressen_US
dc.relation.isversionofdoi://10.1084/jem.20090639en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757891/pdf/en_US
dash.licenseLAA
dc.titleRetinoic Acid Can Enhance Conversion of Naive into Regulatory T Cells Independently of Secreted Cytokinesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalThe Journal of Experimental Medicineen_US
dash.depositing.authorDaniel, Carolin
dc.date.available2011-11-01T15:10:18Z
dash.affiliation.otherHMS^Pathologyen_US
dash.affiliation.otherHMS^Pathologyen_US
dc.identifier.doi10.1084/jem.20090639*
dash.authorsorderedfalse
dash.contributor.affiliatedKim, Hye-Jung
dash.contributor.affiliatedvon Boehmer, Harald
dash.contributor.affiliatedDaniel, Carolin


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record