dc.contributor.author | Nolting, Jens | |
dc.contributor.author | Reuter, Sabine | |
dc.contributor.author | Stuelten, Christina | |
dc.contributor.author | Li, Peng | |
dc.contributor.author | Sucov, Henry | |
dc.contributor.author | Kim, Byung-Gyu | |
dc.contributor.author | Letterio, John J. | |
dc.contributor.author | Kretschmer, Karsten | |
dc.contributor.author | Daniel, Carolin | |
dc.contributor.author | Kim, Hye-Jung | |
dc.contributor.author | von Boehmer, Harald | |
dc.date.accessioned | 2011-11-01T15:10:18Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Nolting, Jens, Carolin Daniel, Sabine Reuter, Christina Stuelten, Peng Li, Henry Sucov, Byung-Gyu Kim, et al. 2009. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. The Journal of Experimental Medicine 206(10): 2131-2139. | en_US |
dc.identifier.issn | 0022-1007 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:5336035 | |
dc.description.abstract | It has been reported that retinoic acid (RA) enhances regulatory T (T reg) cell conversion by inhibiting the secretion of cytokines that interfere with conversion. This report shows that these conclusions provide a partial explanation at best. First, RA not only interfered with cytokine secretion but also with the ability of these cytokines to inhibit T reg cell conversion of naive T cells. Furthermore, RA enhanced conversion even in the absence of inhibitory cytokines. The latter effect depended on the RA receptor α (RARα) but did not require Smad3, despite the fact that RA enhanced Smad3 expression. The RARα1 isoform was not essential for RA-dependent enhancement of transforming growth factor β–driven conversion, suggesting that conversion can also be mediated by RARα2. Interleukin (IL)-6 strongly reduced RARα expression levels such that a deficiency of the predominant RARα1 isoform leaves too little RARα2 for RA to inhibit the generation of Th17 cells in the presence of IL-6. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | The Rockefeller University Press | en_US |
dc.relation.isversionof | doi://10.1084/jem.20090639 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757891/pdf/ | en_US |
dash.license | LAA | |
dc.title | Retinoic Acid Can Enhance Conversion of Naive into Regulatory T Cells Independently of Secreted Cytokines | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | The Journal of Experimental Medicine | en_US |
dash.depositing.author | Daniel, Carolin | |
dc.date.available | 2011-11-01T15:10:18Z | |
dash.affiliation.other | HMS^Pathology | en_US |
dash.affiliation.other | HMS^Pathology | en_US |
dc.identifier.doi | 10.1084/jem.20090639 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | von Boehmer, Harald | |
dash.contributor.affiliated | Daniel, Carolin | |
dash.contributor.affiliated | Kim, Hye-Jung | |