A Revival of the B Cell Paradigm for Rheumatoid Arthritis Pathogenesis?
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CitationBenoist, Christophe, and Diane Mathis. 2000. A revival of the B cell paradigm for rheumatoid arthritis pathogenesis? Arthritis Research 2(2): 90-94.
AbstractDominant paradigms for the understanding of rheumatoid arthritis (RA) pathogenesis have changed over the years. A predominant role of B lymphocytes, and perhaps of the rheumatoid factor they produced, was initially invoked. In more recent years, recognition of antigens in the joint by T cells sparking an inflammatory cascade has been a more favored interpretation. Here, we re-examine some of the arguments that underpin this proposed role of joint T cells, in light of recent results from transgenic mice in which a self-reactive T-cell receptor provokes disease, but from outside the joint and indirectly via B lymphocytes and immunoglobulins.
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