In Vivo Analysis of the Notch Receptor S1 Cleavage

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In Vivo Analysis of the Notch Receptor S1 Cleavage

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Title: In Vivo Analysis of the Notch Receptor S1 Cleavage
Author: Lake, Robert J.; Grimm, Lisa M.; Veraksa, Alexey; Banos, Andrew; Artavanis-Tsakonas, Spyros

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Citation: Lake, Robert J., Lisa M. Grimm, Alexey Veraksa, Andrew Banos, and Spyros Artavanis-Tsakonas. 2009. In Vivo Analysis of the Notch Receptor S1 Cleavage. PLoS ONE 4(8): e6728.
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Abstract: A ligand-independent cleavage (S1) in the extracellular domain of the mammalian Notch receptor results in what is considered to be the canonical heterodimeric form of Notch on the cell surface. The in vivo consequences and significance of this cleavage on Drosophila Notch signaling remain unclear and contradictory. We determined the cleavage site in Drosophila and examined its in vivo function by a transgenic analysis of receptors that cannot be cleaved. Our results demonstrate a correlation between loss of cleavage and loss of in vivo function of the Notch receptor, supporting the notion that S1 cleavage is an in vivo mechanism of Notch signal control.
Published Version: doi:10.1371/journal.pone.0006728
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726433/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5346713
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