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dc.contributor.authorZanetti, Giorgio
dc.contributor.authorGiardina, Richard
dc.contributor.authorPlatt, Richard
dc.date.accessioned2011-11-16T17:46:10Z
dc.date.issued2001
dc.identifier.citationZanetti, Giorgio, Richard Giardina, and Richard Platt. 2001. Intraoperative redosing of cefazolin and risk for surgical site infection in cardiac surgery. Emerging Infectious Diseases 7(5): 828-831.en_US
dc.identifier.issn1080-6040en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5346775
dc.description.abstractIntraoperative redosing of prophylactic antibiotics is recommended for prolonged surgical procedures, although its efficacy has not been assessed. We retrospectively compared the risk of surgical site infections in 1,548 patients who underwent cardiac surgery lasting >240 min after preoperative administration of cefazolin prophylaxis. The overall risk of surgical site infection was similar among patients with (43 [9.4%] of 459) and without (101 [9.3%] of 1,089) intraoperative redosing (odds ratio [OR] 1.01, 95% confidence interval [CI] 0.70-1.47). However, redosing was beneficial in procedures lasting >400 min: infection occurred in 14 (7.7%) of 182 patients with redosing and in 32 (16.0%) of 200 patients without (adjusted OR 0.44, 95% CI 0.23-0.86). Intraoperative redosing of cefazolin was associated with a 16% reduction in the overall risk for surgical site infection after cardiac surgery, including procedures lasting <240 min.en_US
dc.language.isoen_USen_US
dc.publisherCenters for Disease Controlen_US
dc.relation.isversionofdoi:10.3201/eid0705.010509en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631868/pdf/en_US
dash.licenseLAA
dc.titleIntraoperative Redosing of Cefazolin and Risk for Surgical Site Infection in Cardiac Surgeryen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEmerging Infectious Diseasesen_US
dash.depositing.authorPlatt, Richard
dc.date.available2011-11-16T17:46:10Z
dash.affiliation.otherHMS^Population Medicineen_US
dc.identifier.doi10.3201/eid0705.010509*
dash.contributor.affiliatedPlatt, Richard


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