A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale

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Author
Bohland, Jason W.
Wu, Caizhi
Barbas, Helen
Bokil, Hemant
Bota, Mihail
Cline, Hollis T.
Freed, Peter J.
Greenspan, Ralph J.
Haber, Suzanne N.
Hawrylycz, Michael
Hilgetag, Claus C.
Jones, Allan
Karten, Harvey J.
Kleinfeld, David
Kötter, Rolf
Lester, Henry A.
Lin, John M.
Mikula, Shawn
Panksepp, Jaak
Price, Joseph L.
Safdieh, Joseph
Schiff, Nicholas D.
Stillman, Bruce W.
Svoboda, Karel
Swanson, Larry W.
Toga, Arthur W.
Van Essen, David C.
Mitra, Partha P.
Sporns, Olaf
Doyle, John C.
Huang, Z. Josh
Jones, Edward G.
Watson, James D.
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1371/journal.pcbi.1000334Metadata
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Bohland, Jason W., Caizhi Wu, Helen Barbas, Hemant Bokil, Mihail Bota, Hans C. Breiter, Hollis T. Cline, and et al. 2009. A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS Computational Biology 5(3): e1000334.Abstract
In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale of resolution suitable for comprehensive, brainwide coverage, using injections of tracers or viral vectors. We detail the scientific and medical rationale and briefly review existing knowledge and experimental techniques. We define a set of desiderata, including brainwide coverage; validated and extensible experimental techniques suitable for standardization and automation; centralized, open-access data repository; compatibility with existing resources; and tractability with current informatics technology. We discuss a hypothetical but tractable plan for mouse, additional efforts for the macaque, and technique development for human. We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655718/pdf/Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:5346779
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