A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale
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A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale
| Title: | A Proposal for a Coordinated Effort for the Determination of Brainwide Neuroanatomical Connectivity in Model Organisms at a Mesoscopic Scale |
| Author: |
Bohland, Jason W.; Wu, Caizhi; Barbas, Helen; Bokil, Hemant; Bota, Mihail; Cline, Hollis T.; Freed, Peter J.; Greenspan, Ralph J.; Haber, Suzanne N.; Hawrylycz, Michael; Hilgetag, Claus C.; Jones, Allan; Karten, Harvey J.; Kleinfeld, David; Kötter, Rolf; Lester, Henry A.; Lin, John M.; Mikula, Shawn; Panksepp, Jaak; Price, Joseph L.; Safdieh, Joseph; Schiff, Nicholas D.; Stillman, Bruce W.; Svoboda, Karel; Swanson, Larry W.; Toga, Arthur W.; Van Essen, David C.; Mitra, Partha P.; Sporns, Olaf; Breiter, Hans Charles; Doyle, John C.; Herrera, Daniel Gustavo; Huang, Z. Josh; Jones, Edward G.; Mensh, Brett Daren; Saper, Clifford B.; Schmahmann, Jeremy Dan; Watson, James D.
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Bohland, Jason W., Caizhi Wu, Helen Barbas, Hemant Bokil, Mihail Bota, Hans C. Breiter, Hollis T. Cline, and et al. 2009. A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS Computational Biology 5(3): e1000334. |
| Full Text & Related Files: |
2655718.pdf (653.9Kb; PDF) 
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| Abstract: | In this era of complete genomes, our knowledge of neuroanatomical circuitry remains surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into brain function. Here we advocate for a concerted effort to fill this gap, through systematic, experimental mapping of neural circuits at a mesoscopic scale of resolution suitable for comprehensive, brainwide coverage, using injections of tracers or viral vectors. We detail the scientific and medical rationale and briefly review existing knowledge and experimental techniques. We define a set of desiderata, including brainwide coverage; validated and extensible experimental techniques suitable for standardization and automation; centralized, open-access data repository; compatibility with existing resources; and tractability with current informatics technology. We discuss a hypothetical but tractable plan for mouse, additional efforts for the macaque, and technique development for human. We estimate that the mouse connectivity project could be completed within five years with a comparatively modest budget. |
| Published Version: | doi://10.1371/journal.pcbi.1000334 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655718/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:5346779 |
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