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dc.contributor.authorWalkley, Carl R
dc.contributor.authorSankaran, Vijay Ganesh
dc.contributor.authorOrkin, Stuart Holland
dc.date.accessioned2011-11-16T18:15:37Z
dc.date.issued2008
dc.identifier.citationWalkley, Carl R, Vijay G Sankaran, and Stuart H Orkin. 2008. Rb and hematopoiesis: Stem cells to anemia. Cell Division 3: 13.en_US
dc.identifier.issn1747-1028en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5346782
dc.description.abstractThe retinoblastoma protein, Rb, was one of the first tumor suppressor genes identified as a result of the familial syndrome retinoblastoma. In the period since its identification and cloning a large number of studies have described its role in various cellular processes. The application of conditional somatic mutation with lineage and temporally controlled gene deletion strategies, thus circumventing the lethality associated with germ-line deletion of Rb, have allowed for a reanalysis of the in vivo role of Rb. In the hematopoietic system, such approaches have led to new insights into stem cell biology and the role of the microenvironment in regulating hematopoietic stem cell fate. They have also clarified the role that Rb plays during erythropoiesis and defined a novel mechanism linking mitochondrial function to terminal cell cycle withdrawal. These studies have shed light on the in vivo role of Rb in the regulation of hematopoiesis and also prompt further analysis of the role that Rb plays in both the regulation of hematopoietic stem cells and the terminal differentiation of their progeny.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/1747-1028-3-13en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562376/pdf/en_US
dash.licenseLAA
dc.titleRb and Hematopoiesis: Stem Cells to Anemiaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalCell Divisionen_US
dash.depositing.authorOrkin, Stuart Holland
dc.date.available2011-11-16T18:15:37Z
dash.affiliation.otherHMS^Stipendees - MD-PhDen_US
dash.affiliation.otherHMS^Stipendees - Div of Medical Sciencesen_US
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dash.affiliation.otherHMS^Pediatrics-Children's Hospitalen_US
dc.identifier.doi10.1186/1747-1028-3-13*
dash.contributor.affiliatedOrkin, Stuart
dash.contributor.affiliatedSankaran, Vijay


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