Elucidation of the Potential Roles of Matrix Metalloproteinases in Skeletal Biology

DSpace/Manakin Repository

Elucidation of the Potential Roles of Matrix Metalloproteinases in Skeletal Biology

Citable link to this page

 

 
Title: Elucidation of the Potential Roles of Matrix Metalloproteinases in Skeletal Biology
Author: Krane, Stephen Martin
Citation: Krane, Stephen M. 2003. Elucidation of the potential roles of matrix metalloproteinases in skeletal biology. Arthritis Research & Therapy 5(1): 2-4.
Full Text & Related Files:
Abstract: Irreversible destruction of joint structures is a major feature of osteoarthritis and rheumatoid arthritis. Fibrillar collagens in bone, cartilage and other soft tissues are critical for optimal joint form and function. Several approaches can be used to ascertain the role of collagenases, matrix metalloproteinases, in proteolysis of joint collagens in arthritis. These approaches include identifying spontaneous genetic disorders of the enzymes and substrates in humans and animals, as well as engineering mutations in the genes that encode these proteins in mice. Insights gained from such studies can be used to design new therapies to interrupt these catabolic events.
Published Version: doi:10.1186/ar600
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154421/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5347436
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters