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dc.contributor.authorCosta-Guda, Jessica
dc.contributor.authorTokura, Takehiko
dc.contributor.authorRoth, Sanford Irwin
dc.contributor.authorArnold, Andrew
dc.date.accessioned2011-11-17T16:18:28Z
dc.date.issued2007
dc.identifier.citationCosta-Guda, Jessica, Takehiko Tokura, Sanford I Roth, and Andrew Arnold. 2007. Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas. BMC Endocrine Disorders 7: 8.en_US
dc.identifier.issn1472-6823en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5347479
dc.description.abstractBackground: The potential pathogenetic significance of mitochondrial DNA (mtDNA) mutations in tumorigenesis is controversial. We hypothesized that benign tumorigenesis of a slowly replicating tissue like the human parathyroid might constitute an especially fertile ground on which a selective advantage conferred by mtDNA mutation could be manifested and might contribute to the oxyphilic phenotype observed in a subset of parathyroid tumors. Methods: We sought acquired mitochondrial DNA mutations by sequencing the entire 16.6 kb mitochondrial genome of each of thirty sporadic parathyroid adenomas (18 chief cell and 12 oxyphil cell), eight independent, polyclonal, parathyroid primary chief cell hyperplasias plus corresponding normal control samples, five normal parathyroid glands, and one normal thyroid gland. Results: Twenty-seven somatic mutations were identified in 15 of 30 (9 of 12 oxyphil adenomas, 6 of 18 chief cell) parathyroid adenomas studied. No somatic mutations were observed in the hyperplastic parathyroid glands. Conclusion: Features of the somatic mutations suggest that they may confer a selective advantage and contribute to the molecular pathogenesis of parathyroid adenomas. Importantly, the statistically significant differences in mutation prevalence in oxyphil vs. chief cell adenomas also suggest that mtDNA mutations may contribute to the oxyphil phenotype.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/1472-6823-7-8en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099428/pdf/en_US
dash.licenseLAA
dc.titleMitochondrial DNA Mutations in Oxyphilic and Chief Cell Parathyroid Adenomasen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Endocrine Disordersen_US
dash.depositing.authorRoth, Sanford Irwin
dc.date.available2011-11-17T16:18:28Z
dash.affiliation.otherHMS^Pathologyen_US
dc.identifier.doi10.1186/1472-6823-7-8*
dash.contributor.affiliatedRoth, Sanford Irwin


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