Show simple item record

dc.contributor.authorD'Agata, Erika Maria Concetta
dc.contributor.authorDupont-Rouzeyrol, Myrielle
dc.contributor.authorMagal, Pierre
dc.contributor.authorOlivier, Damien
dc.contributor.authorRuan, Shigui
dc.date.accessioned2011-11-29T05:26:49Z
dc.date.issued2008
dc.identifier.citationD'Agata, Erika M. C., Myrielle Dupont-Rouzeyrol, Pierre Magal, Damien Olivier, and Shigui Ruan. 2008. The Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteria. PLoS ONE 3(12): e4036.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5355101
dc.description.abstractBackgroud: The emergence and ongoing spread of antimicrobial-resistant bacteria is a major public health threat. Infections caused by antimicrobial-resistant bacteria are associated with substantially higher rates of morbidity and mortality compared to infections caused by antimicrobial-susceptible bacteria. The emergence and spread of these bacteria is complex and requires incorporating numerous interrelated factors which clinical studies cannot adequately address. Methods/Principal Findings: A model is created which incorporates several key factors contributing to the emergence and spread of resistant bacteria including the effects of the immune system, acquisition of resistance genes and antimicrobial exposure. The model identifies key strategies which would limit the emergence of antimicrobial-resistant bacterial strains. Specifically, the simulations show that early initiation of antimicrobial therapy and combination therapy with two antibiotics prevents the emergence of resistant bacteria, whereas shorter courses of therapy and sequential administration of antibiotics promote the emergence of resistant strains. Conclusions/Significance: The principal findings suggest that (i) shorter lengths of antibiotic therapy and early interruption of antibiotic therapy provide an advantage for the resistant strains, (ii) combination therapy with two antibiotics prevents the emergence of resistance strains in contrast to sequential antibiotic therapy, and (iii) early initiation of antibiotics is among the most important factors preventing the emergence of resistant strains. These findings provide new insights into strategies aimed at optimizing the administration of antimicrobials for the treatment of infections and the prevention of the emergence of antimicrobial resistance.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0004036en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603320/pdf/en_US
dash.licenseLAA
dc.subjectmathematicsen_US
dc.subjectnonlinear dynamicsen_US
dc.subjectmicrobiologyen_US
dc.subjectimmunity to infectionsen_US
dc.subjectinfectious diseasesen_US
dc.subjectantimicrobials and drug resistanceen_US
dc.subjectbacterial infectionsen_US
dc.subjectnosocomial and healthcare-associated infectionsen_US
dc.subjectpublic health and epidemiologyen_US
dc.titleThe Impact of Different Antibiotic Regimens on the Emergence of Antimicrobial-Resistant Bacteriaen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorD'Agata, Erika Maria Concetta
dc.date.available2011-11-29T05:26:49Z
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dc.identifier.doi10.1371/journal.pone.0004036*
dash.contributor.affiliatedD'Agata, Erika Maria Concetta


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record