Assessment of the Frequency-Domain Multi-Distance Method to Evaluate the Brain Optical Properties: Monte Carlo Simulations from Neonate to Adult

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Assessment of the Frequency-Domain Multi-Distance Method to Evaluate the Brain Optical Properties: Monte Carlo Simulations from Neonate to Adult

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Title: Assessment of the Frequency-Domain Multi-Distance Method to Evaluate the Brain Optical Properties: Monte Carlo Simulations from Neonate to Adult
Author: Sliva, Danielle D.; Dehaes, Mathieu; Grant, P. Ellen; Roche-Labarbe, Nadege; Pienaar, Rudolph; Boas, David A.; Franceschini, Maria A.; Selb, Juliette J

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Citation: Dehaes, Mathieu, P. Ellen Grant, Danielle D. Sliva, Nadege Roche-Labarbe, Rudolph Pienaar, David A. Boas, Maria Angela Franceschini, and Juliette Selb. 2011. Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult. Biomedical Optics Express 2(3): 552-567.
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Abstract: The near infrared spectroscopy (NIRS) frequency-domain multi-distance (FD-MD) method allows for the estimation of optical properties in biological tissue using the phase and intensity of radiofrequency modulated light at different source-detector separations. In this study, we evaluated the accuracy of this method to retrieve the absorption coefficient of the brain at different ages. Synthetic measurements were generated with Monte Carlo simulations in magnetic resonance imaging (MRI)-based heterogeneous head models for four ages: newborn, 6 and 12 month old infants, and adult. For each age, we determined the optimal set of source-detector separations and estimated the corresponding errors. Errors arise from different origins: methodological (FD-MD) and anatomical (curvature, head size and contamination by extra-cerebral tissues). We found that the brain optical absorption could be retrieved with an error between 8-24% in neonates and infants, while the error increased to 19-44% in adults over all source-detector distances. The dominant contribution to the error was found to be the head curvature in neonates and infants, and the extra-cerebral tissues in adults.
Published Version: doi:10.1364/BOE.2.000552
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047361/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:5358868
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