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dc.contributor.authorDehaes, Mathieu
dc.contributor.authorGrant, P. Ellen
dc.contributor.authorSliva, Danielle D.
dc.contributor.authorRoche-Labarbe, Nadege
dc.contributor.authorPienaar, Rudolph
dc.contributor.authorBoas, David A.
dc.contributor.authorFranceschini, Maria A.
dc.contributor.authorSelb, Juliette J
dc.date.accessioned2011-12-01T18:12:01Z
dc.date.issued2011
dc.identifier.citationDehaes, Mathieu, P. Ellen Grant, Danielle D. Sliva, Nadege Roche-Labarbe, Rudolph Pienaar, David A. Boas, Maria Angela Franceschini, and Juliette Selb. 2011. Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult. Biomedical Optics Express 2(3): 552-567.en_US
dc.identifier.issn2156-7085en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5358868
dc.description.abstractThe near infrared spectroscopy (NIRS) frequency-domain multi-distance (FD-MD) method allows for the estimation of optical properties in biological tissue using the phase and intensity of radiofrequency modulated light at different source-detector separations. In this study, we evaluated the accuracy of this method to retrieve the absorption coefficient of the brain at different ages. Synthetic measurements were generated with Monte Carlo simulations in magnetic resonance imaging (MRI)-based heterogeneous head models for four ages: newborn, 6 and 12 month old infants, and adult. For each age, we determined the optimal set of source-detector separations and estimated the corresponding errors. Errors arise from different origins: methodological (FD-MD) and anatomical (curvature, head size and contamination by extra-cerebral tissues). We found that the brain optical absorption could be retrieved with an error between 8-24% in neonates and infants, while the error increased to 19-44% in adults over all source-detector distances. The dominant contribution to the error was found to be the head curvature in neonates and infants, and the extra-cerebral tissues in adults.en_US
dc.language.isoen_USen_US
dc.publisherOptical Society of Americaen_US
dc.relation.isversionofdoi:10.1364/BOE.2.000552en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047361/pdf/en_US
dash.licenseLAA
dc.titleAssessment of the Frequency-Domain Multi-Distance Method to Evaluate the Brain Optical Properties: Monte Carlo Simulations from Neonate to Adulten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBiomedical Optics Expressen_US
dash.depositing.authorDehaes, Mathieu
dc.date.available2011-12-01T18:12:01Z
dash.affiliation.other100174en_US
dash.affiliation.otherHMS^Radiology-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Health Sciences and Technologyen_US
dc.identifier.doi10.1364/BOE.2.000552*
dash.contributor.affiliatedPienaar, Rudolph
dash.contributor.affiliatedSelb, Juliette J
dash.contributor.affiliatedDehaes, Mathieu
dash.contributor.affiliatedFranceschini, Maria
dash.contributor.affiliatedGrant, P.
dash.contributor.affiliatedBoas, David


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