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dc.contributor.authorWyller, Vegard Bruun
dc.contributor.authorBarbieri, Riccardo
dc.contributor.authorSaul, J. Philip
dc.date.accessioned2011-12-01T19:45:20Z
dc.date.issued2010
dc.identifier.citationWyller, Vegard Bruun, Riccardo Barbieri, and J. Philip Saul. 2010. Blood pressure variability and closed-loop baroreflex assessment in adolescent chronic fatigue syndrome during supine rest and orthostatic stress. European Journal of Applied Physiology 111(3): 497-507.en_US
dc.identifier.issn1439-6319en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5358876
dc.description.abstractHemodynamic abnormalities have been documented in the chronic fatigue syndrome (CFS), indicating functional disturbances of the autonomic nervous system responsible for cardiovascular regulation. The aim of this study was to explore blood pressure variability and closed-loop baroreflex function at rest and during mild orthostatic stress in adolescents with CFS. We included a consecutive sample of 14 adolescents 12 to 18 years old with CFS diagnosed according to a thorough and standardized set of investigations and 56 healthy control subjects of equal sex and age distribution. Heart rate and blood pressure were recorded continuously and non-invasively during supine rest and during lower body negative pressure (LBNP) of negative 20mmHg to simulate mild orthostatic stress. Indices of blood pressure variability and baroreflex function (alpha-gain) were computed from monovariate and bivariate spectra in the low-frequency (LF) band (0.04 to 0.15 Hz) and the high-frequency (HF) band (0.15 to 0.50 Hz), using an autoregressive algorithm. Variability of systolic blood pressure in the HF range was lower among CFS patients as compared to controls both at rest and during LBNP. During LBNP, compared to controls, alpha-gain HF decreased more, and alpha-gain LF and the ratio of alpha-gain LF/alpha-gain HF increased more in CFS patients, all suggesting greater shift from parasympathetic to sympathetic baroreflex control. CFS in adolescents is characterized by reduced systolic blood pressure variability and a sympathetic predominance of baroreflex heart rate control during orthostatic stress. These findings may have implications for the pathophysiology of CFS in adolescents.en_US
dc.language.isoen_USen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofdoi:10.1007/s00421-010-1670-9en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037975/pdf/en_US
dash.licenseLAA
dc.subjectblood pressure variabilityen_US
dc.subjectbaroreflex sensitivityen_US
dc.subjectchronic fatigue syndromeen_US
dc.subjectautonomic nervous systemen_US
dc.subjectcardiovascular regulationen_US
dc.titleBlood Pressure Variability and Closed-Loop Baroreflex Assessment in Adolescent Chronic Fatigue Syndrome During Supine Rest and Orthostatic Stressen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEuropean Journal of Applied Physiologyen_US
dash.depositing.authorBarbieri, Riccardo
dc.date.available2011-12-01T19:45:20Z
dash.affiliation.other100164en_US
dc.identifier.doi10.1007/s00421-010-1670-9*
dash.contributor.affiliatedBarbieri, Riccardo


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