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dc.contributor.authorWhitney, James B.
dc.contributor.authorHraber, Peter T.
dc.contributor.authorLuedemann, Corinne
dc.contributor.authorGiorgi, Elena E.
dc.contributor.authorDaniels, Marcus G.
dc.contributor.authorBhattacharya, Tanmoy
dc.contributor.authorRao, Srinivas S.
dc.contributor.authorMascola, John R.
dc.contributor.authorNabel, Gary J.
dc.contributor.authorKorber, Bette T.
dc.contributor.authorLetvin, Norman Lee
dc.date.accessioned2011-12-01T20:01:09Z
dc.date.issued2011
dc.identifier.citationWhitney, James B., Peter T. Hraber, Corinne Luedemann, Elena E. Giorgi, Marcus G. Daniels, Tanmoy Bhattacharya, Srinivas S. Rao, et al. 2011. Genital tract sequestration of SIV following acute infection. PLoS Pathogens 7(2): e1001293.en_US
dc.identifier.issn1553-7366en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5358881
dc.description.abstractWe characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus "spillover" into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.ppat.1001293en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040679/pdf/en_US
dash.licenseLAA
dc.titleGenital Tract Sequestration of SIV following Acute Infectionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Pathogensen_US
dash.depositing.authorWhitney, James B.
dc.date.available2011-12-01T20:01:09Z
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dc.identifier.doi10.1371/journal.ppat.1001293*
dash.authorsorderedfalse
dash.contributor.affiliatedWhitney, James
dash.contributor.affiliatedLetvin, Norman Lee


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