dc.contributor.author | Boyden, Steven Edward | |
dc.contributor.author | Kunkel, Louis Martens | |
dc.date.accessioned | 2011-12-06T19:47:11Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Boyden, Steven E., and Louis M. Kunkel. 2010. High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. PLoS ONE 5(8): e12432. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:5361101 | |
dc.description.abstract | Background: Human lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity. Accordingly, siblings of centenarians have a dramatically higher probability of reaching extreme old age than the general population. Methodology/Principal Findings To map the loci conferring a survival advantage, we performed the second genomewide linkage scan on human longevity and the first using a high-density marker panel of single nucleotide polymorphisms. By systematically testing a range of minimum age cutoffs in 279 families with multiple long-lived siblings, we identified a locus on chromosome 3p24-22 with a genomewide significant allele-sharing LOD score of 4.02 (empirical P = 0.037) and a locus on chromosome 9q31-34 with a highly suggestive LOD score of 3.89 (empirical P = 0.054). The empirical P value for the combined result was 0.002. A third novel locus with a LOD score of 4.05 on chromosome 12q24 was detected in a subset of the data, and we also obtained modest evidence for a previously reported interval on chromosome 4q22-25. Conclusions/Significance Our linkage data should facilitate the discovery of both common and rare variants that determine genetic variability in lifespan. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi://10.1371/journal.pone.0012432 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930849/pdf/ | en_US |
dash.license | LAA | |
dc.subject | genetics and genomics | en_US |
dc.subject | complex traits | en_US |
dc.subject | genetics of disease | en_US |
dc.subject | medical genetics | en_US |
dc.title | High-Density Genomewide Linkage Analysis of Exceptional Human Longevity Identifies Multiple Novel Loci | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS ONE | en_US |
dash.depositing.author | Kunkel, Louis Martens | |
dc.date.available | 2011-12-06T19:47:11Z | |
dash.affiliation.other | HMS^Genetics | en_US |
dash.affiliation.other | HMS^Pediatrics-Children's Hospital | en_US |
dc.identifier.doi | 10.1371/journal.pone.0012432 | * |
dash.contributor.affiliated | Kunkel, Louis | |
dash.contributor.affiliated | Boyden, Steven Edward | |