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dc.contributor.authorCarlson, Bradley A.
dc.contributor.authorYoo, Min-Hyuk
dc.contributor.authorSano, Yasuyo
dc.contributor.authorSengupta, Aniruddha
dc.contributor.authorKim, Jin Young
dc.contributor.authorIrons, Robert
dc.contributor.authorGladyshev, Vadim
dc.contributor.authorHatfield, Dolph L.
dc.contributor.authorPark, Jin Mo
dc.date.accessioned2011-12-06T20:07:05Z
dc.date.issued2009
dc.identifier.citationCarlson, Bradley A, Min-Hyuk Yoo, Yasuyo Sano, Aniruddha Sengupta, Jin Young Kim, Robert Irons, Vadim N Gladyshev, Dolph L Hatfield, and Jin Mo Park. 2009. Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression. BMC Immunology 10: 57.en_US
dc.identifier.issn1471-2172en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5361169
dc.description.abstractBackground: Selenium, a micronutrient whose deficiency in diet causes immune dysfunction and inflammatory disorders, is thought to exert its physiological effects mostly in the form of selenium-containing proteins (selenoproteins). Incorporation of selenium into the amino acid selenocysteine (Sec), and subsequently into selenoproteins is mediated by \(Sec\) \(tRNA^{[Ser]Sec}\). Results: To define macrophage-specific selenoprotein functions, we generated mice with the \(Sec\) \(tRNA^{[Ser]Sec}\) gene specifically deleted in myeloid cells. These mutant mice were devoid of the "selenoproteome" in macrophages, yet exhibited largely normal inflammatory responses. However, selenoprotein deficiency led to aberrant expression of extracellular matrix-related genes, and diminished migration of macrophages in a protein gel matrix. Conclusion: Selenium status may affect immune defense and tissue homeostasis through its effect on selenoprotein expression and the trafficking of tissue macrophages.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/1471-2172-10-57en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774298/pdf/en_US
dash.licenseLAA
dc.subjectselenocysteineen_US
dc.subjecttransfer-RNAen_US
dc.subjectsignal-transductionen_US
dc.subjectinnate immunityen_US
dc.subjectkappa-Ben_US
dc.subjectactivationen_US
dc.subjectseleniumen_US
dc.subjectmiceen_US
dc.subjectinhibitionen_US
dc.subjectTRSPen_US
dc.titleSelenoproteins Regulate Macrophage Invasiveness and Extracellular Matrix-related Gene Expressionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Immunologyen_US
dash.depositing.authorPark, Jin Mo
dc.date.available2011-12-06T20:07:05Z
dash.affiliation.otherHMS^Dermatology-Massachusetts General Hospitalen_US
dc.identifier.doi10.1186/1471-2172-10-57*
dash.contributor.affiliatedPark, Jin Mo
dash.contributor.affiliatedGladyshev, Vadim


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