Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder
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Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder
| Title: | Scaling Behavior of Human Locomotor Activity Amplitude: Association with Bipolar Disorder |
| Author: |
Indic, Premananda; Salvatore, Paola; Maggini, Carlo; Ghidini, Stefano; Ferraro, Gabriella; Baldessarini, Ross John; Murray, Greg
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Indic, Premananda, Paola Salvatore, Carlo Maggini, Stefano Ghidini, Gabriella Ferraro, Ross J. Baldessarini, and Greg Murray. 2011. Scaling behavior of human locomotor activity amplitude: association with bipolar disorder. PLoS ONE 6(5): e20650. |
| Full Text & Related Files: |
3105113.pdf (701.8Kb; PDF) 
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| Abstract: | Scale invariance is a feature of complex biological systems, and abnormality of multi-scale behaviour may serve as an indicator of pathology. The hypothalamic suprachiasmatic nucleus (SCN) is a major node in central neural networks responsible for regulating multi-scale behaviour in measures of human locomotor activity. SCN also is implicated in the pathophysiology of bipolar disorder (BD) or manic-depressive illness, a severe, episodic disorder of mood, cognition and behaviour. Here, we investigated scaling behaviour in actigraphically recorded human motility data for potential indicators of BD, particularly its manic phase. A proposed index of scaling behaviour (Vulnerability Index [VI]) derived from such data distinguished between: [i] healthy subjects at high versus low risk of mood disorders; [ii] currently clinically stable BD patients versus matched controls; and [iii] among clinical states in BD patients. |
| Published Version: | doi:10.1371/journal.pone.0020650 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105113/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978615 |
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