Genotyping Analyses of Tuberculosis Cases in U.S.- and Foreign-Born Massachusetts Residents
View/ Open
Author
Sharnprapai, Sharon
Suruki, Robert
Corkren, Edward
Etkind, Sue
Driscoll, Jeffrey
McGarry, Michael
Published Version
https://doi.org/10.3201/eid0811.020370Metadata
Show full item recordCitation
Sharnprapai, Sharon, Ann C. Miller, Robert Suruki, Edward Corkren, Sue Etkind, Jeffrey Driscoll, Michael McGarry, and Edward Nardell. 2002. Genotyping analyses of tuberculosis cases in U.S.- and foreign-born Massachusetts residents. Emerging Infectious Diseases 8(11): 1239-1245.Abstract
We used molecular genotyping to further understand the epidemiology and transmission patterns of tuberculosis (TB) in Massachusetts. The study population included 983 TB patients whose cases were verified by the Massachusetts Department of Public Health between July 1, 1996, and December 31, 2000, and for whom genotyping results and information on country of origin were available. Two hundred seventy-two (28%) of TB patients were in genetic clusters, and isolates from U.S-born were twice as likely to cluster as those of foreign-born (odds ratio [OR] 2.29, 95% confidence interval [CI] 1.69, 3.12). Our results suggest that restriction fragment length polymorphism analysis has limited capacity to differentiate TB strains when the isolate contains six or fewer copies of IS6110, even with spoligotyping. Clusters of TB patients with more than six copies of IS6110 were more likely to have epidemiologic connections than were clusters of TB patients with isolates with few copies of IS6110 (OR 8.01, 95%; CI 3.45,18.93).Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738545/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978676
Collections
- HMS Scholarly Articles [17922]
- SPH Scholarly Articles [6362]
Contact administrator regarding this item (to report mistakes or request changes)