Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR
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dc.contributor.author |
Wang, Fengfei |
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dc.contributor.author |
Xiao, Peigen |
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dc.contributor.author |
Yang, Junshan |
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dc.contributor.author |
Wu, Erxi |
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dc.contributor.author |
Tian, Ze
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dc.contributor.author |
Shen, Jie
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dc.contributor.author |
Lei, Hetian
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dc.contributor.author |
Kazlauskas, Andrius
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dc.contributor.author |
Kohane, Isaac Samuel
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dc.date.accessioned |
2011-12-30T02:21:46Z |
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dc.date.issued |
2011 |
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dc.identifier.citation |
Tian, Ze, Jie Shen, Fengfei Wang, Peigen Xiao, Junshan Yang, Hetian Lei, Andrius Kazlauskas, Isaac S. Kohane, and Erxi Wu. 2011. Cambogin is preferentially cytotoxic to cells expressing PDGFR. PLoS ONE 6(6): e21370. |
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dc.identifier.issn |
1932-6203 |
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dc.identifier.uri |
http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978718 |
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dc.description.abstract |
Platelet-derived growth factor receptors (PDGFRs) have been implicated in a wide array of human malignancies, including medulloblastoma (MB), the most common brain tumor of childhood. Although significant progress in MB biology and therapeutics has been achieved during the past decades, MB remains a horrible challenge to the physicians and researchers. Therefore, novel inhibitors targeting PDGFR signaling pathway may offer great promise for the treatment of MB. In the present study, we investigated the cytotoxicity and mechanisms of cambogin in Daoy MB cells. Our results show that cambogin triggers significant S phase cell cycle arrest and apoptosis via down regulation of cyclin A and E, and activation of caspases. More importantly, further mechanistic studies demonstrated that cambogin inhibits PDGFR signaling in Daoy and genetically defined mouse embryo fibroblast (MEF) cell lines. These results suggest that cambogin is preferentially cytotoxic to cells expressing PDGFR. Our findings may provide a novel approach by targeting PDGFR signaling against MB. |
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en_US |
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dc.publisher |
Public Library of Science |
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dc.relation.isversionof |
doi:10.1371/journal.pone.0021370 |
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dc.relation.hasversion |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119700/pdf/ |
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dash.license |
LAA |
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dc.subject |
endocrine physiology |
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dc.subject |
endocrine system |
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dc.subject |
growth factors |
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dc.subject |
cancer genetics |
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head and neck tumors |
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dc.subject |
chemotherapy and drug treatment |
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dc.subject |
molecular cell biology |
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dc.subject |
cancers and neoplasms |
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dc.title |
Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR |
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dc.type |
Journal Article |
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dc.description.version |
Version of Record |
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dc.relation.journal |
PLoS ONE |
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dash.depositing.author |
Tian, Ze
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dc.date.available |
2011-12-30T02:21:46Z |
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dash.affiliation.other |
HMS^Medicine-Brigham and Women's Hospital |
en_US |
dash.affiliation.other |
HMS^Countway Library of Medicine |
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dash.affiliation.other |
HMS^Medicine-Brigham and Women's Hospital |
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dash.affiliation.other |
HMS^Pediatrics-Children's Hospital |
en_US |
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