Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR

Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR

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Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR

dc.contributor.author	Wang, Fengfei
dc.contributor.author	Xiao, Peigen
dc.contributor.author	Yang, Junshan
dc.contributor.author	Wu, Erxi
dc.contributor.author	Tian, Ze
dc.contributor.author	Shen, Jie
dc.contributor.author	Lei, Hetian
dc.contributor.author	Kazlauskas, Andrius
dc.contributor.author	Kohane, Isaac Samuel
dc.date.accessioned	2011-12-30T02:21:46Z
dc.date.issued	2011
dc.identifier.citation	Tian, Ze, Jie Shen, Fengfei Wang, Peigen Xiao, Junshan Yang, Hetian Lei, Andrius Kazlauskas, Isaac S. Kohane, and Erxi Wu. 2011. Cambogin is preferentially cytotoxic to cells expressing PDGFR. PLoS ONE 6(6): e21370.	en_US
dc.identifier.issn	1932-6203	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978718
dc.description.abstract	Platelet-derived growth factor receptors (PDGFRs) have been implicated in a wide array of human malignancies, including medulloblastoma (MB), the most common brain tumor of childhood. Although significant progress in MB biology and therapeutics has been achieved during the past decades, MB remains a horrible challenge to the physicians and researchers. Therefore, novel inhibitors targeting PDGFR signaling pathway may offer great promise for the treatment of MB. In the present study, we investigated the cytotoxicity and mechanisms of cambogin in Daoy MB cells. Our results show that cambogin triggers significant S phase cell cycle arrest and apoptosis via down regulation of cyclin A and E, and activation of caspases. More importantly, further mechanistic studies demonstrated that cambogin inhibits PDGFR signaling in Daoy and genetically defined mouse embryo fibroblast (MEF) cell lines. These results suggest that cambogin is preferentially cytotoxic to cells expressing PDGFR. Our findings may provide a novel approach by targeting PDGFR signaling against MB.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Public Library of Science	en_US
dc.relation.isversionof	doi:10.1371/journal.pone.0021370	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119700/pdf/	en_US
dash.license	LAA
dc.subject	endocrine physiology	en_US
dc.subject	endocrine system	en_US
dc.subject	growth factors	en_US
dc.subject	cancer genetics	en_US
dc.subject	head and neck tumors	en_US
dc.subject	chemotherapy and drug treatment	en_US
dc.subject	molecular cell biology	en_US
dc.subject	cancers and neoplasms	en_US
dc.title	Cambogin is Preferentially Cytotoxic to Cells Expressing PDGFR	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	PLoS ONE	en_US
dash.depositing.author	Tian, Ze
dc.date.available	2011-12-30T02:21:46Z
dash.affiliation.other	HMS^Medicine-Brigham and Women's Hospital	en_US
dash.affiliation.other	HMS^Countway Library of Medicine	en_US
dash.affiliation.other	HMS^Medicine-Brigham and Women's Hospital	en_US
dash.affiliation.other	HMS^Pediatrics-Children's Hospital	en_US