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dc.contributor.authorElemans, Marjet
dc.contributor.authorThiebaut, Rodolphe
dc.contributor.authorKaur, Amitinder
dc.contributor.authorAsquith, Becca
dc.date.accessioned2011-12-30T02:45:10Z
dc.date.issued2011
dc.identifier.citationElemans, Marjet, Rodolphe Thiebaut, Amitinder Kaur, and Becca Asquith. 2011. Quantification of the relative importance of CTL, B cell, NK cell, and target cell limitation in the control of primary SIV-infection. PLoS Computational Biology 7(3): e1001103.en_US
dc.identifier.issn1553-734Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5978722
dc.description.abstractCD8\(^+\) cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, B cells and target cell limitation have all been suggested to play a role in the control of SIV and HIV-1 infection. However, previous research typically studied each population in isolation leaving the magnitude, relative importance and in vivo relevance of each effect unclear. Here we quantify the relative importance of CTLs, NK cells, B cells and target cell limitation in controlling acute SIV infection in rhesus macaques. Using three different methods, we find that the availability of target cells and CD8\(^+\) T cells are important predictors of viral load dynamics. If CTL are assumed to mediate this anti-viral effect via a lytic mechanism then we estimate that CTL killing is responsible for approximately 40% of productively infected cell death, the remaining cell death being attributable to intrinsic, immune (CD8\(^+\) T cell, NK cell, B cell) -independent mechanisms. Furthermore, we find that NK cells have little impact on the death rate of infected CD4\(^+\) cells and that their net impact is to increase viral load. We hypothesize that NK cells play a detrimental role in SIV infection, possibly by increasing T cell activation.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionof10.1371/journal.pcbi.1001103en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048377/pdf/en_US
dash.licenseLAA
dc.titleQuantification of the Relative Importance of CTL, B Cell, NK Cell, and Target Cell Limitation in the Control of Primary SIV-Infectionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Computational Biologyen_US
dash.depositing.authorKaur, Amitinder
dc.date.available2011-12-30T02:45:10Z
dash.affiliation.other100175en_US
dc.identifier.doi10.1371/journal.pcbi.1001103*
dash.contributor.affiliatedKaur, Amitinder


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