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dc.contributor.authorRen, Cizao
dc.contributor.authorVokonas, Pantel S
dc.contributor.authorSuh MacIntosh, Helen H.
dc.contributor.authorFang, Shona C.
dc.contributor.authorChristiani, David C.
dc.contributor.authorSchwartz, Joel David
dc.date.accessioned2012-01-01T22:48:34Z
dc.date.issued2010
dc.identifier.citationRen, Cizao, Pantel S Vokonas, Helen Suh, Shona Fang, David C Christiani, and Joel Schwartz. 2010. Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions. Environmental Health 9: 78.en_US
dc.identifier.issn1476-069Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5978736
dc.description.abstractBackground: Air pollution is associated with adverse human health, but mechanisms through which pollution exerts effects remain to be clarified. One suggested pathway is that pollution causes oxidative stress. If so, oxidative stress-related genotypes may modify the oxidative response defenses to pollution exposure. Methods: We explored the potential pathway by examining whether an array of oxidative stress-related genes (twenty single nucleotide polymorphisms, SNPs in nine genes) modified associations of pollutants (organic carbon (OC), ozone and sulfate) with urinary 8-hydroxy-2-deoxygunosine (8-OHdG), a biomarker of oxidative stress among the 320 aging men. We used a Multiple Testing Procedure in R modified by our team to identify the significance of the candidate genes adjusting for a priori covariates. Results: We found that glutathione S-tranferase P1 (GSTP1, rs1799811), M1 and catalase (rs2284367) and group-specific component (GC, rs2282679, rs1155563) significantly or marginally significantly modified effects of OC and/or sulfate with larger effects among those carrying the wild type of GSTP1, catalase, non-wild type of GC and the non-null of GSTM1. Conclusions: Polymorphisms of oxidative stress-related genes modified effects of OC and/or sulfate on 8-OHdG, suggesting that effects of OC or sulfate on 8-OHdG and other endpoints may be through the oxidative stress pathway.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi://10.1186/1476-069X-9-78en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016327/pdf/en_US
dash.licenseLAA
dc.titleEffect Modification of Air Pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by Genotypes: An Application of the Multiple Testing Procedure to Identify Significant SNP Interactionsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Healthen_US
dash.depositing.authorSuh MacIntosh, Helen H.
dc.date.available2012-01-01T22:48:34Z
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dash.affiliation.otherHMS^Medicine-Massachusetts General Hospitalen_US
dash.affiliation.otherSPH^Environmental+Occupational Medicine+Epien_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dc.identifier.doi10.1186/1476-069X-9-78*
dash.authorsorderedfalse
dash.contributor.affiliatedFang, Shona C
dash.contributor.affiliatedSuh MacIntosh, Helen H.
dash.contributor.affiliatedVokonas, Pantel
dash.contributor.affiliatedSchwartz, Joel
dash.contributor.affiliatedChristiani, David
dc.identifier.orcid0000-0002-2557-150X


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