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dc.contributor.authorHartong, Dyonne T.
dc.contributor.authorMcGee, Terri L.
dc.contributor.authorSandberg, Michael Arthur
dc.contributor.authorBerson, Eliot Lawrence
dc.contributor.authorAsselbergs, Folkert W.
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorDe Vivo, Immaculata
dc.contributor.authorDryja, Thaddeus Peter
dc.date.accessioned2012-01-03T05:11:50Z
dc.date.issued2009
dc.identifier.citationHartong, Dyonne T., Terri L. McGee, Michael A. Sandberg, Eliot L. Berson, Folkert W. Asselbergs, Pim van der Harst, Immaculata De Vivo, and Thaddeus P. Dryja. 2009. Search for a correlation between telomere length and severity of retinitis pigmentosa due to the dominant rhodopsin Pro23His mutation. Molecular Vision 15: 592-597.en_US
dc.identifier.issn1090-0535en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:5978764
dc.description.abstractPurpose: Great variation exists in the age of onset of symptoms and the severity of disease at a given age in patients with retinitis pigmentosa (RP). The final pathway for this disease may involve apoptotic photoreceptor cell death. Telomere length is associated with biologic aging, senescence, and apoptosis. We evaluated whether the length of telomeres in leukocytes correlated with the severity of RP in patients with the Pro23His rhodopsin mutation who have shown marked heterogeneity in disease severity.Methods We evaluated 122 patients with the Pro23His rhodopsin mutation. The patients’ retinal function was stratified according to their 30-Hz cone electroretinogram (ERG). The length of telomeres in leukocytes was measured by the quantitative real time polymerase chain reaction (qRT–PCR) method in the 15 patients with the highest age-adjusted 30-Hz ERG amplitudes and in the 15 patients with the lowest amplitudes. Results: Mean leukocyte telomere length was similar in the 15 patients with the highest cone ERG amplitudes (median: 0.40 units; interquartile range 0.36–0.56) and the 15 patients with the lowest cone amplitudes (median: 0.41 units; inter quartile range 0.34 −0.64; p=0.95). Conclusions: We found no evidence for an association between telomere length and the severity of RP as monitored by the cone ERG in patients with the Pro23His rhodopsin mutation.en_US
dc.language.isoen_USen_US
dc.publisherMolecular Visionen_US
dc.relation.isversionofhttp://www.molvis.org/molvis/en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661004/pdf/en_US
dash.licenseLAA
dc.titleSearch for a Correlation between Telomere Length and Severity of Retinitis Pigmentosa due to the Dominant Rhodopsin Pro23His Mutationen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalMolecular Visionen_US
dash.depositing.authorSandberg, Michael Arthur
dc.date.available2012-01-03T05:11:50Z
dash.affiliation.otherHMS^Ophthalmologyen_US
dash.affiliation.otherHMS^Ophthalmologyen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Ophthalmologyen_US
dash.contributor.affiliatedSandberg, Michael
dash.contributor.affiliatedBerson, Eliot L.
dash.contributor.affiliatedDryja, Thaddeus
dash.contributor.affiliatedDe Vivo, Immaculata


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