dc.contributor.author | Qi, Lu | |
dc.contributor.author | Rifai, Nader | |
dc.contributor.author | Hu, Frank B. | |
dc.date.accessioned | 2012-01-03T05:25:15Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Qi, Lu, Nader Rifai, and Frank B. Hu. 2009. Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women. Diabetes 58(1): 275-278. | en_US |
dc.identifier.issn | 0012-1797 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:5978768 | |
dc.description.abstract | OBJECTIVE—Recent genome-wide association studies (GWASs) related common variants in the interleukin-6 (Il-6) receptor (IL6R) gene to plasma C-reactive protein (CRP) concentrations. Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and the interactions between IL6R variants and CRP in relation to diabetes risk. RESEARCH DESIGN AND METHODS—Plasma CRP and IL-6 levels and 10 IL6R polymorphisms were determined in a nested case-control study of 633 diabetic and 692 healthy Caucasian women. RESULTS—In both nondiabetic and diabetic women, IL6R polymorphisms were associated with plasma CRP levels, independent of IL-6 concentration. After adjustment of IL-6 levels, CRP concentrations in the genotype AA, AC, and CC of the GWAS polymorphism rs8192284 were 0.32, 0.26, and 0.24 pg/ml, respectively, among nondiabetic women (P for trend = 0.003; false discovery rate [FDR] = 0.01) and 0.63, 0.48, and 0.43 pg/ml among diabetic women (P for trend less than 0.0001; FDR = 0.0001). Haplotypes inferred from polymorphisms within a linkage disequilibrium block including rs8192284 were also significantly associated with CRP levels (P = 0.0002). In an exploratory analysis, rs8192284 showed significant interactions with CRP levels in relation to diabetes risk (P for interaction = 0.026). The odds ratios across increasing quartiles of CRP were 2.19 (95% CI 1.42–3.36), 2.03 (1.27–3.23), and 2.92 (1.77–4.82) in the carriers of allele-C and 2.21 (1.18–4.12), 3.77 (1.87–7.57), and 5.02 (2.4–10.5) in the noncarriers. CONCLUSIONS—IL6R variants were significantly associated with plasma CRP, independent of IL-6 levels. IL6R variants may interact with CRP in predicting diabetes risk. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | American Diabetes Association | en_US |
dc.relation.isversionof | doi:10.2337/db08-0968 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606885/pdf/ | en_US |
dash.license | LAA | |
dc.title | Interleukin-6 Receptor Gene, Plasma C-Reactive Protein, and Diabetes Risk in Women | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Diabetes | en_US |
dash.depositing.author | Qi, Lu | |
dc.date.available | 2012-01-03T05:25:15Z | |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | SPH^Nutrition | en_US |
dash.affiliation.other | HMS^Pathology | en_US |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | SPH^Nutrition | en_US |
dc.identifier.doi | 10.2337/db08-0968 | * |
dash.contributor.affiliated | Rifai, Nader | |
dash.contributor.affiliated | Qi, Lu | |
dash.contributor.affiliated | Hu, Frank | |