Association of Expired Nitric Oxide with Occupational Particulate Exposure

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Association of Expired Nitric Oxide with Occupational Particulate Exposure

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Title: Association of Expired Nitric Oxide with Occupational Particulate Exposure
Author: Wand, Matthew P; Mukherjee, Sutapa; Kim, Jee Young; Hauser, Russ B.; Herrick, Robert F.; Christiani, David C.

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Citation: Kim, Jee Young, Matthew P. Wand, Russ Hauser, Sutapa Mukherjee, Robert F. Herrick, and David C. Christiani. 2003. Association of expired nitric oxide with occupational particulate exposure. Environmental Health Perspectives 111(5): 676-680.
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Abstract: Particulate air pollution has been associated with adverse respiratory health effects. This study assessed the utility of expired nitric oxide to detect acute airway responses to metal-containing fine particulates. Using a repeated-measures study design, we investigated the association between the fractional concentration of expired nitric oxide (F\(_E\)NO) and exposure to particulate matter with an aerodynamic mass median diameter of less than or equal to 2.5 micro m (PM\(_{2.5}\)) in boilermakers exposed to residual oil fly ash and metal fumes. Subjects were monitored for 5 days during boiler repair overhauls in 1999 (n = 20) or 2000 (n = 14). The Wilcoxon median baseline F\(_E\)NO was 10.6 ppb [95% confidence interval (CI): 9.1, 12.7] in 1999 and 7.4 ppb (95% CI: 6.7, 8.0) in 2000. The Wilcoxon median PM\(_{2.5}\) 8-hr time-weighted average was 0.56 mg/m(3) (95% CI: 0.37, 0.93) in 1999 and 0.86 mg/m(3) (95% CI: 0.65, 1.07) in 2000. F\(_E\)NO levels during the work week were significantly lower than baseline F\(_E\)NO in 1999 (p < 0.001). A significant inverse exposure-response relationship between log-transformed F\(_E\)NO and the previous workday's PM\(_{2.5}\) concentration was found in 1999, after adjusting for smoking status, age, and sampling year. With each 1 mg/m\(^3\) incremental increase in PM\(_{2.5}\) exposure, log F\(_E\)NO decreased by 0.24 (95% CI: -0.38, -0.10) in 1999. The lack of an exposure-response relationship between PM\(_{2.5}\) exposure and F\(_E\)NO in 2000 could be attributable to exposure misclassification resulting from the use of respirators. In conclusion, occupational exposure to metal-containing fine particulates was associated with significant decreases in F\(_E\)NO in a survey of workers with limited respirator usage.
Published Version: doi:10.1289/ehp.5880
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