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dc.contributor.authorMacCallum, Gail
dc.contributor.authorCanner, Marina J.
dc.contributor.authorGold, Diane R.
dc.contributor.authorLitonjua, Augusto Ampil
dc.contributor.authorZanobetti, Antonella
dc.contributor.authorCoull, Brent Andrew
dc.contributor.authorSchwartz, Joel David
dc.contributor.authorVerrier, Richard Leonard
dc.contributor.authorNearing, Bruce David
dc.contributor.authorSuh MacIntosh, Helen H.
dc.contributor.authorStone, Peter Howard
dc.date.accessioned2012-01-04T20:31:50Z
dc.date.issued2005
dc.identifier.citationGold, Diane R., Augusto A. Litonjua, Antonella Zanobetti, Brent A. Coull, Joel Schwartz, Gail MacCallum, Richard L. Verrier, et al. 2005. Air Pollution and ST-Segment Depression in Elderly Subjects. Environmental Health Perspectives 113(7): 883-887.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:6340135
dc.description.abstractIncreased levels of daily ambient particle pollution have been associated with increased risk of cardiovascular morbidity. Black carbon (BC) is a measure of the traffic-related component of particles. We investigated associations between ambient pollution and ST-segment levels in a repeated-measures study including 269 observations on 24 active Boston residents 61–88 years of age, each observed up to 12 times from June through September 1999. The protocol involved continuous Holter electrocardiogram monitoring including 5 min of rest, 5 min of standing, 5 min of exercise outdoors, 5 min of recovery, and 20 cycles of paced breathing. Pollution-associated ST-depression was estimated for a 10th- to 90th-percentile change in BC. We calculated the average ST-segment level, referenced to the P-R isoelectric values, for each portion of the protocol. The mean BC level in the previous 12 hr, and the BC level 5 hr before testing, predicted ST-segment depression in most portions of the protocol, but the effect was strongest in the postexercise periods. During post-exercise rest, an elevated BC level was associated with −0.1 mm ST-segment depression (p = 0.02 for 12-hr mean BC; p = 0.001 for 5-hr BC) in continuous models. Elevated BC also predicted increased risk of ST-segment depression ≥0.5 mm among those with at least one episode of that level of ST-segment depression. Carbon monoxide was not a confounder of this association. ST-segment depression, possibly representing myocardial ischemia or inflammation, is associated with increased exposure to particles whose predominant source is traffic.en_US
dc.language.isoen_USen_US
dc.publisherNational Institue of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.7737en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257650/pdf/en_US
dash.licenseLAA
dc.subjectair pollutionen_US
dc.subjectcardiologyen_US
dc.subjectelderlyen_US
dc.subjectparticlesen_US
dc.subjectST-segment depressionen_US
dc.subjecttrafficen_US
dc.subjectenvironmental medicineen_US
dc.titleAir Pollution and ST-Segment Depression in Elderly Subjectsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorGold, Diane R.
dc.date.available2012-01-04T20:31:50Z
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Exposure Epidemiology and Risk Programen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherSPH^Biostatisticsen_US
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dash.affiliation.otherSPH^Molecular+Integrative Physiological Sci Progen_US
dash.affiliation.otherHMS^Medicine- Beth Israel-Deaconessen_US
dc.identifier.doi10.1289/ehp.7737*
dash.authorsorderedfalse
dash.contributor.affiliatedStone, Peter
dash.contributor.affiliatedVerrier, Richard
dash.contributor.affiliatedNearing, Bruce
dash.contributor.affiliatedSuh MacIntosh, Helen H.
dash.contributor.affiliatedGold, Diane
dash.contributor.affiliatedLitonjua, Augusto A.
dash.contributor.affiliatedZanobetti, Antonella
dash.contributor.affiliatedCoull, Brent
dash.contributor.affiliatedSchwartz, Joel
dc.identifier.orcid0000-0002-2557-150X


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