Concentrated Ambient Particles Alter Myocardial Blood Flow During Acute Ischemia in Conscious Canines

DSpace/Manakin Repository

Concentrated Ambient Particles Alter Myocardial Blood Flow During Acute Ischemia in Conscious Canines

Citable link to this page

 

 
Title: Concentrated Ambient Particles Alter Myocardial Blood Flow During Acute Ischemia in Conscious Canines
Author: Bartoli, Carlo R.; Wellenius, Gregory A.; Akiyama, Ichiro; Okabe, Kazunori; Coull, Brent Andrew; Diaz, Edgar; Lawrence, Joy E.; Verrier, Richard Leonard; Godleski, John Joseph

Note: Order does not necessarily reflect citation order of authors.

Citation: Bartoli, Carlo R., Gregory A. Wellenius, Brent A. Coull, Ichiro Akiyama, Edgar A. Diaz, Joy Lawrence, Kazunori Okabe, Richard L. Verrier, and John J. Godleski. 2009. Concentrated ambient particles alter myocardial blood flow during acute ischemia in conscious canines. Environmental Health Perspectives 117(3): 333-337.
Full Text & Related Files:
Abstract: Background: Experimental and observational studies have demonstrated that short-term exposure to ambient particulate matter (PM) exacerbates myocardial ischemia. Objectives: We conducted this study to investigate the effects of concentrated ambient particles (CAPs) on myocardial blood flow during myocardial ischemia in chronically instrumented conscious canines. Methods: Eleven canines were instrumented with a balloon occluder around the left anterior descending coronary artery and catheters for determination of myocardial blood flow using fluorescent microspheres. Telemetric electrocardiographic and blood pressure monitoring was available for four of these animals. After recovery, we exposed animals by inhalation to 5 hr of either filtered air or CAPs (mean concentration ± SD, 349.0 ± 282.6 μg/m\(^{3}\)) in a crossover protocol. We determined myocardial blood flow during a 5-min coronary artery occlusion immediately after each exposure. Data were analyzed using mixed models for repeated measures. The primary analysis was based on four canines that completed the protocol. Results: CAPs exposure decreased total myocardial blood flow during coronary artery occlusion by 0.12 mL/min/g (p < 0.001) and was accompanied by a 13% (p < 0.001) increase in coronary vascular resistance. Rate–pressure product, an index of myocardial oxygen demand, did not differ by exposure (p = 0.90). CAPs effects on myocardial blood flow were significantly more pronounced in myocardium within or near the ischemic zone versus more remote myocardium (p interaction < 0.001). Conclusions: These results suggest that PM exacerbates myocardial ischemia by increased coronary vascular resistance and decreased myocardial perfusion. Further studies are needed to elucidate the mechanism of these effects.
Published Version: doi://10.1289/ehp.11380
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661899/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:7349718
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters