Show simple item record

dc.contributor.authorvan Oijen, Marieke
dc.contributor.authorIrizarry, Michael C.
dc.contributor.authorGrodstein, Francine
dc.contributor.authorRosas, Herminia Diana
dc.contributor.authorHyman, Bradley Theodore
dc.contributor.authorGrowdon, John Herbert
dc.contributor.authorDe Vivo, Immaculata
dc.contributor.authorKhoury, Joseph
dc.date.accessioned2012-01-09T00:54:40Z
dc.date.issued2008
dc.identifier.citationGrodstein, Francine, Marieke van Oijen, Michael C. Irizarry, H. Diana Rosas, Bradley T. Hyman, John H. Growdon, and Immaculata De Vivo. 2008. Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study. PLoS ONE 3(2): e1590.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:7349726
dc.description.abstractBackground: Dementia takes decades to develop, and effective prevention will likely require early intervention. Thus, it is critical to identify biomarkers of preclinical disease, allowing targeting of high-risk subjects for preventive efforts. Since telomeres shorten with age and oxidative stress, both of which are important contributors to the onset of dementia, telomere length might be a valuable biomarker. Methodology/Principal Findings: Among 62 participants of the Nurses' Health Study, we conducted neurologic evaluations, including patient and caregiver interviews, physical exam, neurologic exam, and neuropsychologic testing. We also conducted magnetic resonance imaging (MRI) in a sample of 29 of these women. In these preliminary data, after adjustment for numerous health and lifestyle factors, we found that truncated telomeres in peripheral blood leukocytes segregate with preclinical dementia states, including mild cognitive impairment (MCI); the odds of MCI were 12-fold higher (odds ratio = 12.00, 95% confidence interval 1.24–116.5) for those with shorter telomere length compared to longer telomere length. In addition, decreasing telomere length was strongly related to decreasing hippocampal volume (p = 0.038). Conclusions: These preliminary data suggest that telomere length may be a possible early marker of dementia risk, and merits further study in large, prospective investigations.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi://10.1371/journal.pone.0001590en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536511/pdf/en_US
dash.licenseLAA
dc.subjectgeriatricsen_US
dc.subjectdementiaen_US
dc.titleShorter Telomeres May Mark Early Risk of Dementia: Preliminary Analysis of 62 Participants from the Nurses' Health Studyen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorGrodstein, Francine
dc.date.available2012-01-09T00:54:40Z
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dash.affiliation.otherHMS^Neurology-Massachusetts General Hospitalen_US
dash.affiliation.otherHMS^Neurology-Massachusetts General Hospitalen_US
dash.affiliation.otherSPH^Epidemiologyen_US
dash.affiliation.otherHMS^Medicine-Brigham and Women's Hospitalen_US
dc.identifier.doi10.1371/journal.pone.0001590*
dash.authorsorderedfalse
dash.contributor.affiliatedKhoury, Joseph
dash.contributor.affiliatedGrowdon, John
dash.contributor.affiliatedDe Vivo, Immaculata
dash.contributor.affiliatedRosas, Herminia
dash.contributor.affiliatedGrodstein, Francine
dash.contributor.affiliatedHyman, Bradley


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record