dc.contributor.author | Chien, Kuo-Liong | |
dc.contributor.author | Su, Ta-Chen | |
dc.contributor.author | Jeng, Jiann-Shing | |
dc.contributor.author | Hsu, Hsiu-Ching | |
dc.contributor.author | Chang, Wei-Tien | |
dc.contributor.author | Chen, Ming-Fong | |
dc.contributor.author | Lee, Yuan-Teh | |
dc.contributor.author | Berger, Jeffrey S. | |
dc.contributor.author | Hu, Frank B. | |
dc.date.accessioned | 2012-01-09T01:15:29Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Chien, Kuo-Liong, Ta-Chen Su, Jiann-Shing Jeng, Hsiu-Ching Hsu, Wei-Tien Chang, Ming-Fong Chen, Yuan-Teh Lee, and Frank B. Hu. 2008. Carotid artery intima-media thickness, carotid plaque and coronary heart disease and stroke in chinese. PLoS ONE 3(10): 3435. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:7349731 | |
dc.description.abstract | Background: Our aim was to prospectively investigate the association between carotid artery intima-media thickness (IMT) as well as carotid plaque and incidence of coronary heart disease (CHD) and stroke in Chinese, among whom data are limited. Methods and Findings: We conducted a community-based cohort study composed of 2190 participants free of cardiovascular disease at baseline in one community. During a median 10.5-year follow up, we documented 68 new cases of coronary heart disease and 94 cases of stroke. The multivariate relative risks (RRs) associated with a change of 1 standard deviation of maximal common carotid IMT were 1.38 (95% confidence interval [CI], 1.12–1.70) for CHD and 1.47 (95% CI, 1.28–1.69) for stroke. The corresponding RRs with internal carotid IMT were 1.47 (95% CI, 1.21–1.79) for CHD and 1.52 (95% CI, 1.31–1.76) for stroke. Carotid plaque measured by the degree of diameter stenosis was also significantly associated with increased risk of CHD (p for trend<0.0001) and stroke (p for trend<0.0001). However, these associations were largely attenuated when adjusting for IMT measurements. Conclusions: This prospective study indicates a significant association between carotid IMT and incidence of CHD and stroke in Chinese adults. These measurements may be useful for cardiovascular risk assessment and stratification in Chinese. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi://10.1371/journal.pone.0003435 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562458/pdf/ | en_US |
dash.license | LAA | |
dc.subject | cardiovascular disorders | en_US |
dc.subject | peripheral vascular disease | en_US |
dc.subject | neurological disorders | en_US |
dc.subject | neuroimaging | en_US |
dc.title | Carotid Artery Intima-media Thickness, Carotid Plaque and Coronary Heart Disease and Stroke in Chinese | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS ONE | en_US |
dash.depositing.author | Hu, Frank B. | |
dc.date.available | 2012-01-09T01:15:29Z | |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | SPH^Nutrition | en_US |
dc.identifier.doi | 10.1371/journal.pone.0003435 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Hu, Frank | |