JunB Transcription Factor Maintains Skeletal Muscle Mass and Promotes Hypertrophy

JunB Transcription Factor Maintains Skeletal Muscle Mass and Promotes Hypertrophy

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JunB Transcription Factor Maintains Skeletal Muscle Mass and Promotes Hypertrophy

dc.contributor.author	Raffaello, Anna
dc.contributor.author	Milan, Giulia
dc.contributor.author	Masiero, Eva
dc.contributor.author	Carnio, Silvia
dc.contributor.author	Lanfranchi, Gerolamo
dc.contributor.author	Sandri, Marco
dc.contributor.author	Goldberg, Alfred L.
dc.contributor.author	Lee, Dong-Hoon
dc.date.accessioned	2012-01-09T20:11:40Z
dc.date.issued	2010
dc.identifier.citation	Raffaello, Anna, Giulia Milan, Eva Masiero, Silvia Carnio, Dong-Hoon Lee, Gerolamo Lanfranchi, Alfred Lewis Goldberg, and Marco Sandri. 2010. JunB transcription factor maintains skeletal muscle mass and promotes hypertrophy. The Journal of Cell Biology 191(1): 101-113.	en_US
dc.identifier.issn	0021-9525	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:7351760
dc.description.abstract	The size of skeletal muscle cells is precisely regulated by intracellular signaling networks that determine the balance between overall rates of protein synthesis and degradation. Myofiber growth and protein synthesis are stimulated by the IGF-1/Akt/mammalian target of rapamycin (mTOR) pathway. In this study, we show that the transcription factor JunB is also a major determinant of whether adult muscles grow or atrophy. We found that in atrophying myotubes, JunB is excluded from the nucleus and that decreasing JunB expression by RNA interference in adult muscles causes atrophy. Furthermore, JunB overexpression induces hypertrophy without affecting satellite cell proliferation and stimulated protein synthesis independently of the Akt/mTOR pathway. When JunB is transfected into denervated muscles, fiber atrophy is prevented. JunB blocks FoxO3 binding to atrogin-1 and MuRF-1 promoters and thus reduces protein breakdown. Therefore, JunB is important not only in dividing populations but also in adult muscle, where it is required for the maintenance of muscle size and can induce rapid hypertrophy and block atrophy.	en_US
dc.language.iso	en_US	en_US
dc.publisher	The Rockefeller University Press	en_US
dc.relation.isversionof	doi://10.1083/jcb.201001136	en_US
dc.relation.hasversion	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953439/pdf/	en_US
dash.license	LAA
dc.title	JunB Transcription Factor Maintains Skeletal Muscle Mass and Promotes Hypertrophy	en_US
dc.type	Journal Article	en_US
dc.description.version	Version of Record	en_US
dc.relation.journal	The Journal of Cell Biology	en_US
dash.depositing.author	Goldberg, Alfred L.
dc.date.available	2012-01-09T20:11:40Z
dash.affiliation.other	HMS^Cell Biology	en_US
dash.affiliation.other	HMS^Cell Biology	en_US